Trabalho de evento-resumo

Type-1 interferons and innate resistance to Trypanosoma cruzi infection (2001)

• Authors:
  • Costa, V M A
  • Mendonça, R. Z.
  • Gresser, I
  • Abrahamsohn, Ises de Almeida
• Autor USP: ABRAHAMSOHN, ISES DE ALMEIDA - ICB
• Unidade: ICB
• Assunto: IMUNOLOGIA
• Language: Inglês
• Abstract: Type I interferons are known for their antiviral activity and their production in viral infections. Objectives: We investigated type I IFN in murine Trypanosoma cruzi infection and their potential role in controlling parasitism, nitric oxide and cytokine production. Methods: Type I IFN production was measured by viral neutralization assay in the presence of anti-IFN-g ?mAb. Results: IFN-I production by infected mice was already detected 24 h after infection in peritoneal macrophages and at later times in the spleen. Resistant C57 BL/6 mice produced 4-10 fold higher levels of type I IFN than susceptible BALB/c or A/J strains. We next investigated the effect of treatment with neutralizing anti- IFN-I Ab or with purified IFN I on NO production by SC from infected mice. Neutralization of endogenously produced IFN-??? in SC cultures (days 3 and 8 of infection) and in infected peritoneal macrophage cultures reduced NO production by 40-50 %. Infection with T.cruzi of 129/Sv mice deprived of the genes coding for the IFN-??? receptor (IFN-??? R KO) resulted in 3-fold increased parasitemia levels in the acute phase as compared to infected wild type matched control mice; no differences in mortality rates were observed.In comparison with wild type controls, the production of NO by T.cruzi-infected peritoneal cell cultures from IFN-??? R KO mice was markedly reduced (80%). Conclusions: Taken together, the results indicate that endogenously produced IFN-I costimulatesNO synthesis by macrophages and contributes to the initial control of parasitism by innate immunity
• Imprenta:
  • Publisher: Comissão de Cultura e Extensão Universitária do ICB/USP
  • Publisher place: São Paulo
  • Date published: 2001
• Source:
  • Título do periódico: Resumos
• Conference titles: Congresso do Instituto de Ciências Biomédicas

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How to cite

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• ABNT

  COSTA, V M A et al. Type-1 interferons and innate resistance to Trypanosoma cruzi infection. 2001, Anais.. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP, 2001. . Acesso em: 01 maio 2024.

• APA

  Costa, V. M. A., Mendonça, R. Z., Gresser, I., & Abrahamsohn, I. de A. (2001). Type-1 interferons and innate resistance to Trypanosoma cruzi infection. In Resumos. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP.

• NLM

  Costa VMA, Mendonça RZ, Gresser I, Abrahamsohn I de A. Type-1 interferons and innate resistance to Trypanosoma cruzi infection. Resumos. 2001 ;[citado 2024 maio 01 ]

• Vancouver

  Costa VMA, Mendonça RZ, Gresser I, Abrahamsohn I de A. Type-1 interferons and innate resistance to Trypanosoma cruzi infection. Resumos. 2001 ;[citado 2024 maio 01 ]

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