Repeated predictable or unpredictable stress effects on NF-KB in central nervous system (CNS) (2002)
- Authors:
- USP affiliated authors: SCAVONE, CRISTOFORO - ICB ; LUCIA, ROBERTO DE - ICB
- Unidade: ICB
- Assunto: FARMACOLOGIA
- Language: Inglês
- Abstract: Several studies propose a role for NF-kB as a signal in the brain during neurodegeneration. In addition, recent evidences suggest that this nuclear factor has a role in glial and neuronal function, including synaptic transmission, development, and plasticity. The aim of this study was to investigate whether acute stress or chronic stress (14 days) can regulate the NF-kappaB activation in the CNS. Adult male Wistar rats were allocated into four groups: control (no-stress), acute stress predictable stress and unpredictable stress. To evaluate the influence of the glucocorticoids in these experiments, another 4 groups of animals were treated with metyrapone (200mg/kg/day) during the stress period. Cerebellum, hippocampus, and striatum were isolated from animals killed 24h after the last stress. Gel mobility shift assay was used to measure changes in NF-kB activation with treatments. The unpredictable stress induced a decrease in NF-kB activity in all brain regions analyzed. Metyrapone treatment blocked this response only in the cerebellum, suggesting that other intracellular pathways may be involved in this adaptative process
- Imprenta:
- Publisher: Comissão de Cultura e Extensão Universitária do ICB/USP
- Publisher place: São Paulo
- Date published: 2002
- Source:
- Título do periódico: Resumos
- Conference titles: Congresso Instituto Ciências Biomédicas, IV
-
ABNT
MUNHOZ, Carolina Demarchi et al. Repeated predictable or unpredictable stress effects on NF-KB in central nervous system (CNS). 2002, Anais.. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP, 2002. . Acesso em: 04 maio 2024. -
APA
Munhoz, C. D., Glezer, I., Kawamoto, E. M., De Lucia, R., Avellar, M. C. W., Da Silva, C. P., & Scavone, C. (2002). Repeated predictable or unpredictable stress effects on NF-KB in central nervous system (CNS). In Resumos. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP. -
NLM
Munhoz CD, Glezer I, Kawamoto EM, De Lucia R, Avellar MCW, Da Silva CP, Scavone C. Repeated predictable or unpredictable stress effects on NF-KB in central nervous system (CNS). Resumos. 2002 ;[citado 2024 maio 04 ] -
Vancouver
Munhoz CD, Glezer I, Kawamoto EM, De Lucia R, Avellar MCW, Da Silva CP, Scavone C. Repeated predictable or unpredictable stress effects on NF-KB in central nervous system (CNS). Resumos. 2002 ;[citado 2024 maio 04 ] - Effects of chronic predictable (PSt) or unpredictable (USt) stress on body weight
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