TNF-a mediates the persistency of stress-induced oxidative/nitrosative status in rat brain (2003)
- Authors:
- Autor USP: SCAVONE, CRISTOFORO - ICB
- Unidade: ICB
- Assunto: FARMACOLOGIA
- Language: Português
- Abstract: Glutamate and cytokines have been proposed to be involved in accumulation of oxidative/nitrosative mediators in brain cortex (FCx) after immobilization stress (IMO). It is important to know if the intensity and/or persistency of stress cause mood disorders and degeneration and whether they are reversible or not. We sought to determine whether repeated exposure to IMO (rIMO) leads to persistent oxidative status in brain. Adults male Wistar rats were immobilized during 6 hours/day during 7 or 14 days (S7, S14). FCx were obtained immediately after the last session of stress or 20h later. rIMO increases iNOS activity after S7 or S14 (S7: 246%; S14: 426%; P<0.05 vs C). This activity returns to basal 20h after S7 but not after S14 (246%; P<0.05 vs C). Similarly, rIMO increases malondialdehyde (MDA, an indicator of lipid peroxidation) accumulation in FCx after S7 and S14 (S7: 65,2%; S14: 103%; P<0.05 vs C). MDA levels return to basal 20h after S7 only.To elucidate the possible mechanisms involved in this short-term persistency of oxidative status, brain levels of TNF-a was determined. TNF-a levels did not increase after S7 nor 20h after S7, but increases after S14 (25%, P<0.05 vs C), and 20h after S14 (26,9%, P<0.05 vs C). These findings indicate that TNF-a accounts for stress-induced persistency of iNOS expression and MDA accumulation after S14, supporting a possible neuroprotective role for specific blockers of the TNF-a effects in this situation
- Imprenta:
- Publisher: Comissão de Pesquisa do ICB/USP
- Publisher place: São Paulo
- Date published: 2003
- Source:
- Título do periódico: Resumos
- Conference titles: Congresso Instituto Ciências Biomédicas, IV
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ABNT
MUNHOZ, Carolina Demarchi et al. TNF-a mediates the persistency of stress-induced oxidative/nitrosative status in rat brain. 2003, Anais.. São Paulo: Comissão de Pesquisa do ICB/USP, 2003. . Acesso em: 01 maio 2024. -
APA
Munhoz, C. D., Scavone, C., Madrigal, J. L. M., García-Bueno, B., Caso, J., Moro, M. A., et al. (2003). TNF-a mediates the persistency of stress-induced oxidative/nitrosative status in rat brain. In Resumos. São Paulo: Comissão de Pesquisa do ICB/USP. -
NLM
Munhoz CD, Scavone C, Madrigal JLM, García-Bueno B, Caso J, Moro MA, Lizasoain I, Leza JC. TNF-a mediates the persistency of stress-induced oxidative/nitrosative status in rat brain. Resumos. 2003 ;[citado 2024 maio 01 ] -
Vancouver
Munhoz CD, Scavone C, Madrigal JLM, García-Bueno B, Caso J, Moro MA, Lizasoain I, Leza JC. TNF-a mediates the persistency of stress-induced oxidative/nitrosative status in rat brain. Resumos. 2003 ;[citado 2024 maio 01 ] - Cellular 'NA POT.+' Pump as a site of action for carbon monoxide and glutamate: a mechanism for long-term modulation of cellular activity
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