Lumphocyte infiltration in a murine asthma model is modulated by nitric oxide (2003)
- Authors:
- Autor USP: NEGRO, SONIA JANCAR - ICB
- Unidade: ICB
- Assunto: IMUNOLOGIA
- Language: Português
- Abstract: Objective: The effect of a nitric oxide synthase inhibitor was studied in a mouse (C57Bl/6) model of allergic lung inflammation. Methods and results: Nitric oxide synthase inhibitor, Nw-nitro-L-arginine methyl ester (L-NAME) and the inactive enantiomer, Nw-nitro-D-arginine methyl ester (D-NAME) was given i.p. to ovalbumin sensitized mice, 30 min before antigen challenge. After 24 h, bronchoalveolar lavage was perfomed for cell analysis and the lungs were removed for evaluation of airway reactivity to metacholine and mucus production. Treatment with L-NAME caused a significant decrease in the number of lymphocytes CD4+ (58.84%), CD8+ (59.71%), B220 (66.67%), Tgd+ (52.46%) and NK1.1+ (71.09%) in the bronchoalveolar lavage fluid. Mucus secretion was significantly reduced (36%) by this treatment and airway hyperreactivity was abolished. Conclusion: These results show that nitric oxide produced in allergic lung inflammation in mice contributes to the infiltration of lymphocytes (CD4+, CD8+, B220, Tgd+ and NK1.1+), airway hiperreactivity and mucus production
- Imprenta:
- Publisher: Comissão de Pesquisa do ICB/USP
- Publisher place: São Paulo
- Date published: 2003
- Source:
- Título do periódico: Resumos
- Conference titles: Congresso Instituto Ciências Biomédicas, IV
-
ABNT
LANDGRAF, Richardt Gama e NEGRO, Sonia Jancar e NOSSI, D. F. Lumphocyte infiltration in a murine asthma model is modulated by nitric oxide. 2003, Anais.. São Paulo: Comissão de Pesquisa do ICB/USP, 2003. . Acesso em: 27 abr. 2024. -
APA
Landgraf, R. G., Negro, S. J., & Nossi, D. F. (2003). Lumphocyte infiltration in a murine asthma model is modulated by nitric oxide. In Resumos. São Paulo: Comissão de Pesquisa do ICB/USP. -
NLM
Landgraf RG, Negro SJ, Nossi DF. Lumphocyte infiltration in a murine asthma model is modulated by nitric oxide. Resumos. 2003 ;[citado 2024 abr. 27 ] -
Vancouver
Landgraf RG, Negro SJ, Nossi DF. Lumphocyte infiltration in a murine asthma model is modulated by nitric oxide. Resumos. 2003 ;[citado 2024 abr. 27 ] - Lymphocyte infiltration in a murine asthma model is modulated by nitric oxide
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