Relationship between major and minor salivary gland mucoepidermoid carcinoma malignancy grading and presence of stromal myofibroblasts: immunohistochemical study (2004)
- Authors:
- USP affiliated authors: NUNES, FABIO DAUMAS - FO ; ARAUJO, NEY SOARES DE - FO
- Unidade: FO
- DOI: 10.1111/j.1600-0714.2004.00111.x
- Subjects: IMUNOHISTOQUÍMICA; CARCINOMA; GLÂNDULAS SALIVARES
- Language: Inglês
- Abstract: OBJECTIVE: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary tumour, classified as low, intermediate and high grade. Myofibroblasts are the main stromal component and are included as prognostic factor in some tumours. The aim of this study was to evaluate the myofibroblasts in the stroma of MEC with possible relationship to malignancy grading. METHODS: Twenty-five cases of MEC (six low grade, 11 intermediate grade, four high grade and four metastasis) were stained for vimentin, desmin and smooth muscle actin (SMA) for the identification of myofibroblasts. Transforming growth factors (TGFbeta1 and TGF 'beta' RII) were also assessed in our study. RESULTS: Myofibroblasts were present in all cases, in amounts varying according to histological grading. TGFbeta1 was positive in squamous cells of intermediate grade tumours, and in the stroma of only four cases. TGF 'beta' RII was positive in most squamous and intermediate cells, regardless of malignancy grading. CONCLUSIONS: Our study showed that the analysis of neoplastic stroma must be added to the studies of neoplastic cells to draw a better picture leading to tumour diagnosis and prognosis
- Imprenta:
- Source:
- Título do periódico: Journal of Oral Pathology and Medicine
- ISSN: 0904-2512
- Volume/Número/Paginação/Ano: v. 33, n. 6, p.335-339, July 2004
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
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ABNT
SOBRAL, Ana Paula Veras et al. Relationship between major and minor salivary gland mucoepidermoid carcinoma malignancy grading and presence of stromal myofibroblasts: immunohistochemical study. Journal of Oral Pathology and Medicine, v. 33, n. 6, p. 335-339, 2004Tradução . . Disponível em: https://doi.org/10.1111/j.1600-0714.2004.00111.x. Acesso em: 23 abr. 2024. -
APA
Sobral, A. P. V., Loducca, S. V. L., Kowalski, L. P., Araújo, V. C. de, Nunes, F. D., & Araújo, N. S. de. (2004). Relationship between major and minor salivary gland mucoepidermoid carcinoma malignancy grading and presence of stromal myofibroblasts: immunohistochemical study. Journal of Oral Pathology and Medicine, 33( 6), 335-339. doi:10.1111/j.1600-0714.2004.00111.x -
NLM
Sobral APV, Loducca SVL, Kowalski LP, Araújo VC de, Nunes FD, Araújo NS de. Relationship between major and minor salivary gland mucoepidermoid carcinoma malignancy grading and presence of stromal myofibroblasts: immunohistochemical study [Internet]. Journal of Oral Pathology and Medicine. 2004 ; 33( 6): 335-339.[citado 2024 abr. 23 ] Available from: https://doi.org/10.1111/j.1600-0714.2004.00111.x -
Vancouver
Sobral APV, Loducca SVL, Kowalski LP, Araújo VC de, Nunes FD, Araújo NS de. Relationship between major and minor salivary gland mucoepidermoid carcinoma malignancy grading and presence of stromal myofibroblasts: immunohistochemical study [Internet]. Journal of Oral Pathology and Medicine. 2004 ; 33( 6): 335-339.[citado 2024 abr. 23 ] Available from: https://doi.org/10.1111/j.1600-0714.2004.00111.x - Immunolocalization of bmp2/4, tgfβ-1 and osteonectin in fibro-osseous lesions of the jaws
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Informações sobre o DOI: 10.1111/j.1600-0714.2004.00111.x (Fonte: oaDOI API)
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