The expression of substance P MRNA in the rat spinal cord submitted to a contusion lesion (2005)
- Authors:
- Autor USP: CHADI, GERSON - ICB
- Unidade: ICB
- Assunto: ANATOMIA
- Language: Português
- Abstract: Objective: The neuropeptide substance P is a neurotransmitter in the central nervous system. The molecule also participates in the neuroplasticity of the spinal cord, especially after injury. Methods and Resulted: Adult rats were submitted to a moderate spinal cord injury by dropping a 10g rod (25mm distance) using the NYU Impactor (Lesion Group). A group of rats was submitted to a sham operation (Sham Group). The animals were sacrificed 3, 7 or 45 days after the surgery and their spinal cords removed. The substance P mRNA signal was achieved in the spinal cord by means of radioactive in situ hybridization and quantified using microdensitometric analysis (optical density). The expression of substance P mRNA signal was increased in anterior horn at thoracic level close to the lesion epicenter [0.047±0.013 (Sham) and 0.119±0.022 (Lesion), p<0.05] 45 days after spinal cord injury. At high thoracic level, the signal in central intermediate gray matter was decreased 7 days post lesion [0.254±0.014 (Sham) and 0.154±0.025 (Lesion), p<0.05], but was increased 45 days after spinal cord injury [0.049±0.009 (Sham) and 0.135±0.03 (Lesion), p<0.05]. A 24% increase was found in laminae IV of the posterior horn at cervical level after 45 days of contusion and a 34% increase was observed in laminae I and II of the gray matter at thoracic level by 3 days. Conclusions: Substance P is synthesized in the spinal cord and may be involved in the local plasticity after lesion
- Imprenta:
- Publisher: Federação de Sociedades de Biologia Experimental
- Publisher place: Águas de Lindóia, São Paulo
- Date published: 2005
- Source:
- Título do periódico: Resumos
- Conference titles: Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE
-
ABNT
ANDRADE, M. S. R. e CHADI, Gerson. The expression of substance P MRNA in the rat spinal cord submitted to a contusion lesion. 2005, Anais.. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental, 2005. . Acesso em: 01 maio 2024. -
APA
Andrade, M. S. R., & Chadi, G. (2005). The expression of substance P MRNA in the rat spinal cord submitted to a contusion lesion. In Resumos. Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental. -
NLM
Andrade MSR, Chadi G. The expression of substance P MRNA in the rat spinal cord submitted to a contusion lesion. Resumos. 2005 ;[citado 2024 maio 01 ] -
Vancouver
Andrade MSR, Chadi G. The expression of substance P MRNA in the rat spinal cord submitted to a contusion lesion. Resumos. 2005 ;[citado 2024 maio 01 ] - On the presence of the bfgf immunoreactivity in the spinal cord and dorsal root ganglia of the adult rat
- Distribution of the bfgf immunoreactivity in the spinal cord and dorsal root ganglia of the adult rat
- Spontaneous wheel running protects nigral striatal dopamine system from 6-hydroxydopamine neurotoxicity
- Maior crescimento de fibras nervosas na região da lesão medular completa tratada com enxerto de fragmentos de nervo ciático em presença do fator neurotrófico derivado de células gliais (gdnf). Estudo imunohistoquímico em ratos
- Efeitos da atividade física espontânea na arborização dendrítica de ratos submetidos à lesão estriatal isquêmica pela endotelina-1
- Immunohistochemistry combined to image analysis in the evaluation of the expression of glial and extracellular basic fibroblast growth factor in the corticospinal tract of the adult rat following a cervical mechanical lesion of the bulbar pyramid
- Stereological analysis of the astroglial and microglial reaction in the axotomized hypoglossal nucleus of the rat
- Neurochemical changes in the afferent and efferent auditory pathways ofthe adult rat following unilateral cochleotomy
- Evidence for a nuclear translocation of the basic fibroblast growth factor in vivo
- Basic fibroblast growth factor immunoreactivity is present in the reactive astrocytes but not reactive microglia in the rat forebrain after the kainate-induced seizures
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
