Effect of sexual steroids on the calcium content of aortic atherosclerotic plaque of oophorectomized rabbits (2005)
- Authors:
- USP affiliated authors: RAMIRES, JOSE ANTONIO FRANCHINI - FM ; ALDRIGHI, JOSE MENDES - FSP
- Unidades: FM; FSP
- DOI: 10.1590/s0100-879x2005000500007
- Subjects: ESTRÓGENOS (FARMACOLOGIA); HORMÔNIOS PROGESTACIONAIS (FARMACOLOGIA); CÁLCIO; ARTERIOSCLEROSE (QUIMIOTERAPIA); AORTA
- Language: Inglês
- Abstract: We determined the effect of conjugated equine estrogen plus medroxyprogesterone acetate on calcium content of aortic atherosclerotic lesions in oophorectomized adult New Zealand rabbits submitted to a cholesterol rich diet. Five groups of 10 animals each were studied: G1 = control, G2 = cholesterol diet only, G3 = diet plus conjugated equine estrogen (0.625 mg/day); G4 and G5 = diet, conjugated equine estrogen (0.625 mg/day) plus medroxyprogesterone acetate (5 and 10 mg/day, respectively). Mean weight varied from 2.7 n 0.27 to 3.1 n 0.20 kg (P = 0.38) between groups at the beginning and 3.1 n 0.27 to 3.5 n 0.20 kg (P = 0.35) at the end of the experiment. Cholesterol and triglyceride levels were determined at the time of oophorectomy, 21 days after surgery (time 0), and at the end of follow-up of 90 days. The planimetric method was used to measure plaque and caryometric method for histopathologic examination of the aorta. Calcium content was determined by the method of von Kossa. A similar increase in cholesterol occurred in all treated groups without differences between them at the end of the study. Groups G4 and G5 had smaller areas of atherosclerotic lesions (2.33 n 2.8 and 2.45 n 2.1 cmy, respectively) than the groups receiving no progestogens (G2: 5.6 n 4 and G3: 4.6 n 2.8 cmy; P = 0.02). The relation between lesion area and total aorta area was smaller in groups treated with combined drugs compared to the groups receiving no progesterone (G4: 14.9 n13 and G5: 14.2 n 13.4 vs G2: 35.8 n 26 and G3: 25 n 8 cmy, respectively; P = 0.017). Oral conjugated equine estrogen (0.625 mg/day) plus medroxyprogesterone acetate (5 or 10 mg/day) provoked a greater reduction in atherosclerotic plaque area and calcium content in treated groups, suggesting a dose-dependent effect
- Imprenta:
- Publisher place: Ribeirão Preto
- Date published: 2005
- Source:
- Título do periódico: Brazilian journal of medical and biological research
- ISSN: 0100-879X
- Volume/Número/Paginação/Ano: v. 38, n. 5, p. 705-711, maio 2005
- Este periódico é de acesso aberto
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: gold
- Licença: cc-by
-
ABNT
ALDRIGHI, José Mendes et al. Effect of sexual steroids on the calcium content of aortic atherosclerotic plaque of oophorectomized rabbits. Brazilian journal of medical and biological research, v. 38, n. 5, p. 705-711, 2005Tradução . . Disponível em: https://doi.org/10.1590/s0100-879x2005000500007. Acesso em: 20 maio 2024. -
APA
Aldrighi, J. M., Lanz, J. R., Mansur, A. P., Martinez, T. L. da R., & Ramires, J. A. F. (2005). Effect of sexual steroids on the calcium content of aortic atherosclerotic plaque of oophorectomized rabbits. Brazilian journal of medical and biological research, 38( 5), 705-711. doi:10.1590/s0100-879x2005000500007 -
NLM
Aldrighi JM, Lanz JR, Mansur AP, Martinez TL da R, Ramires JAF. Effect of sexual steroids on the calcium content of aortic atherosclerotic plaque of oophorectomized rabbits [Internet]. Brazilian journal of medical and biological research. 2005 ; 38( 5): 705-711.[citado 2024 maio 20 ] Available from: https://doi.org/10.1590/s0100-879x2005000500007 -
Vancouver
Aldrighi JM, Lanz JR, Mansur AP, Martinez TL da R, Ramires JAF. Effect of sexual steroids on the calcium content of aortic atherosclerotic plaque of oophorectomized rabbits [Internet]. Brazilian journal of medical and biological research. 2005 ; 38( 5): 705-711.[citado 2024 maio 20 ] Available from: https://doi.org/10.1590/s0100-879x2005000500007 - Prognóstico das doenças cardiovasculares nas mulheres
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Informações sobre o DOI: 10.1590/s0100-879x2005000500007 (Fonte: oaDOI API)
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