Menopausal status: a possible predictive factor for recurrence in women with cancer of the uterine cervix without pelvic lymph node metastasis (2009)
- Authors:
- USP affiliated authors: LATORRE, MARIA DO ROSARIO DIAS DE OLIVEIRA - FSP ; SOARES, FERNANDO AUGUSTO - FO
- Unidades: FSP; FO
- DOI: 10.1016/s0020-7292(09)60692-5
- Subjects: SOBREVIVÊNCIA LIVRE DE DOENÇA (ASPECTOS SOCIOECONÔMICOS;ASPECTOS MÉDICOS); NEOPLASIAS DO COLO UTERINO (FATORES); CARCINOMA; RECIDIVA LOCAL DE NEOPLASIA; FATORES DE RISCO; HISTERECTOMIA (TRATAMENTO); RECIDIVA; MENOPAUSA
- Language: Inglês
- Abstract: Abstract Objectives to evaluate risk factors for recurrence of carcinoma of the uterine cervix among women who had undergone radical hysterectomy without pelvic lymph node metastasis, while taking into consideration not only the classical histopathological factors but also sociodemographic, clinical and treatment-related factors. Study desin This was an exploratory analysis on 233 women with carcinoma of the uterine cervix (stages IB and IIA) who were treated by means of radical hysterectomy and pelvic lymphadenectomy, with free surgical margins and without lymph node metastases on conventional histopathological examination. Women with histologically normal lymph nodes but with micrometastases in the immunohistochemical analysis (AE1/AE3) were excluded. Disease-free survival for sociodemographic, clinical and histopathological variables was calculated using the Kaplan-Meier method. The Cox proportional hazards model was used to identify the independent risk factors for recurrence. Twenty-seven recurrences were recorded (11.6%), of which 18 were pelvic, four were distant, four were pelvic + distant and one was of unknown location. The five-year disease-free survival rate among the study population was 88.4%. The independent risk factors for recurrence in the multivariate analysis were: postmenopausal status (HR 14.1; 95% CI: 3.7-53.6; P < 0.001), absence of or slight inflammatory reaction (HR 7.9; 95% CI: 1.7-36.5; P = 0.008) and invasion of the deepestthird of the cervix (HR 6.1; 95% CI: 1.3-29.1; P = 0.021). Postoperative radiotherapy was identified as a protective factor against recurrence (HR 0.02; 95% CI: 0.001-0.25; P = 0.003). (To continue) Postmenopausal status is a possible independent risk factor for recurrence even when adjusted for classical prognostic factors (such as tumour size, depth of tumour invasion, capillary embolisation) and treatment-related factors (period of treatment and postoperative radiotherapy status)
- Imprenta:
- Source:
- Título do periódico: European Journal of Obstetrics & Gynecology and Reproductive Biology
- ISSN: 0301-2115
- Volume/Número/Paginação/Ano: v. 146, n. 2, p. 204-209, Oct. 2009
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
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ABNT
FREGNANI, José H.T.G et al. Menopausal status: a possible predictive factor for recurrence in women with cancer of the uterine cervix without pelvic lymph node metastasis. European Journal of Obstetrics & Gynecology and Reproductive Biology, v. 146, n. 2, p. 204-209, 2009Tradução . . Disponível em: https://doi.org/10.1016/s0020-7292(09)60692-5. Acesso em: 11 maio 2024. -
APA
Fregnani, J. H. T. G., Latorre, M. do R. D. de O., Novik, P. R., Lopes, A., & Soares, F. A. (2009). Menopausal status: a possible predictive factor for recurrence in women with cancer of the uterine cervix without pelvic lymph node metastasis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 146( 2), 204-209. doi:10.1016/s0020-7292(09)60692-5 -
NLM
Fregnani JHTG, Latorre M do RD de O, Novik PR, Lopes A, Soares FA. Menopausal status: a possible predictive factor for recurrence in women with cancer of the uterine cervix without pelvic lymph node metastasis [Internet]. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2009 ; 146( 2): 204-209.[citado 2024 maio 11 ] Available from: https://doi.org/10.1016/s0020-7292(09)60692-5 -
Vancouver
Fregnani JHTG, Latorre M do RD de O, Novik PR, Lopes A, Soares FA. Menopausal status: a possible predictive factor for recurrence in women with cancer of the uterine cervix without pelvic lymph node metastasis [Internet]. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2009 ; 146( 2): 204-209.[citado 2024 maio 11 ] Available from: https://doi.org/10.1016/s0020-7292(09)60692-5 - Comparison of biological behavior between early-stage adenocarcinoma and squamous cell carcinoma of the uterine cervix
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Informações sobre o DOI: 10.1016/s0020-7292(09)60692-5 (Fonte: oaDOI API)
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