Effect of Zincum metallicum and LPS treatments on femoral bone density in pregnant mice (2015)
- Authors:
- USP affiliated authors: COSTA, CLAUDIO - FO ; ARITA, EMIKO SAITO - FO
- Unidade: FO
- Subjects: DENSIDADE; FÊMUR; OSSO E OSSOS; DENSIDADE
- Language: Inglês
- Abstract: Introduction: Clinical studies have shown that adverse events in childhood can lead to the development of psychiatric disorders, such as anxiety, in adolescence and adulthood in humans. Manipulations with laboratory animals, such as maternal deprivation (MD), are a source of stress for the offspring and can be a useful tool for the understanding how these events in the early period of development can lead to behavioral changes in adulthood. Studies about the use of homeopathic ultra-high dilutions as tools to minimize stress are found in the literature, i.e. Zincum metallicum is used for the treatment of neurological and behavioral symptoms, including: weakening of intellectual functions with brain and nervous exhaustion, loss of vitality, slow comprehension, memory disorder, general tremor and constant movements. These alterations can be characterized as stress-related phenomena in different species. Aim: The aim of this study was to evaluate the long-term effects of homeopathic treatment in animals subjected to stress in their early days (maternal deprivation). This study was approved by the Ethics Committee of the University of Santo Amaro (UNISA), according to Process number 11/2014. Materials and Methods: In this study, newborn female rats were subjected to maternal deprivation and treated from the 10th day of lactation (PND10) until weaning (PND21). The animals were divided in 4 groups: 8 treated with Zincum metallicum 30 cH (Zn30cH); 8 treated with Zincum metallicum 6 cH (Zn6cH); 8 treated with 10% hydroalcoholic solution (medicines in blind trials, identified by codes); and 8 animals who had neither taken anything (“blank control”) nor experienced deprivation. The animals were weighed weekly, from weaning until the end of the experiment, and evaluated in the Open Field (OF) and in the Plus Maze (PM) devices to measure mobility, emotionality and anxiety, in 3 moments: in PND21 (childhood), during puberty
- Imprenta:
- Source:
- Título do periódico: International Journal of High Dilution Research
- ISSN: 1982-6206
- Volume/Número/Paginação/Ano: v.14, n.2, p. 35-39, 2015
- Conference titles: GIRI Meeting
-
ABNT
LEITE, Silvio et al. Effect of Zincum metallicum and LPS treatments on femoral bone density in pregnant mice. International Journal of High Dilution Research. São Paulo: Faculdade de Odontologia, Universidade de São Paulo. . Acesso em: 21 maio 2024. , 2015 -
APA
Leite, S., Dutra-Correa, M., Costa, C., Pecorari, V. G. A., Arita, E. S., Bernardi, M. M., et al. (2015). Effect of Zincum metallicum and LPS treatments on femoral bone density in pregnant mice. International Journal of High Dilution Research. São Paulo: Faculdade de Odontologia, Universidade de São Paulo. -
NLM
Leite S, Dutra-Correa M, Costa C, Pecorari VGA, Arita ES, Bernardi MM, Holandino C, Bonamin LV. Effect of Zincum metallicum and LPS treatments on femoral bone density in pregnant mice. International Journal of High Dilution Research. 2015 ;14( 2): 35-39.[citado 2024 maio 21 ] -
Vancouver
Leite S, Dutra-Correa M, Costa C, Pecorari VGA, Arita ES, Bernardi MM, Holandino C, Bonamin LV. Effect of Zincum metallicum and LPS treatments on femoral bone density in pregnant mice. International Journal of High Dilution Research. 2015 ;14( 2): 35-39.[citado 2024 maio 21 ] - Fluxo de trabalho digital para preservação do rebordo alveolar com enxerto ósseo equino: relato de caso
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