Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical markets (2021)
- Authors:
- Autor USP: EZEAGU, HENRY IFEANYI - FCF
- Unidade: FCF
- Sigla do Departamento: FBF
- DOI: 10.11606/D.9.2021.tde-23022022-163911
- Assunto: COMPRIMIDOS
- Keywords: Comprimidos; Dissolution profile; Dissolution test; Fármacos de baixa solubilidade; Low solubility drugs; Perfil de dissolução; Tablets; Teste de dissolução
- Agências de fomento:
- Language: Inglês
- Abstract: The purpose of this work was to elaborate a diagnosis of the dissolution test in Africa in comparison with Brazil, evaluating the dissolution profile of low solubility drugs such as albendazole, ibuprofen, furosemide, glibenclamide, hydrochlorothiazide and carvedilol to ascertain their quality. The dissolution profiles were evaluated by utilizing the United States Pharmacopeia (USP). The glibenclamide medicine was evaluated according to the Food and Drug Administration (FDA), while a dissolution method was developed for the carvedilol medicine. A filter selection test for all the drugs showed that cannula is suitable for all, except for carvedilol, which is centrifuged. The various brands of Nigerian and Brazilian medicines tested showed some statistical differences. The suitable conditions that allowed the dissolution of carvedilol to be determined were the USP type II apparatus at 75 rpm containing 900 mL of acetate buffer, pH 4.5. The results of the dissolution test showed that out of the 17 different brands of Brazilian medicines and 17 different products from Nigeria, 94.12% and 58.82% passed respectively
- Imprenta:
- Data da defesa: 23.06.2021
- Este periódico é de acesso aberto
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: gold
- Licença: cc-by-nc-sa
-
ABNT
EZEAGU, Henry Ifeanyi. Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical markets. 2021. Dissertação (Mestrado) – Universidade de São Paulo, São Paulo, 2021. Disponível em: https://www.teses.usp.br/teses/disponiveis/9/9139/tde-23022022-163911/. Acesso em: 29 maio 2024. -
APA
Ezeagu, H. I. (2021). Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical markets (Dissertação (Mestrado). Universidade de São Paulo, São Paulo. Recuperado de https://www.teses.usp.br/teses/disponiveis/9/9139/tde-23022022-163911/ -
NLM
Ezeagu HI. Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical markets [Internet]. 2021 ;[citado 2024 maio 29 ] Available from: https://www.teses.usp.br/teses/disponiveis/9/9139/tde-23022022-163911/ -
Vancouver
Ezeagu HI. Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical markets [Internet]. 2021 ;[citado 2024 maio 29 ] Available from: https://www.teses.usp.br/teses/disponiveis/9/9139/tde-23022022-163911/
Informações sobre o DOI: 10.11606/D.9.2021.tde-23022022-163911 (Fonte: oaDOI API)
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