Selenium supplementation during puberty and young adult-hood mitigates obesity-induced metabolic, cellular and epigenetic alterations in male rat physiology (2022)
- Authors:
- Autor USP: PASCOAL, GABRIELA DE FREITAS LAIBER - FCF
- Unidade: FCF
- Sigla do Departamento: FBA
- DOI: 10.11606/T.9.2022.tde-25082022-172904
- Subjects: NUTRIÇÃO EXPERIMENTAL; CIÊNCIA DE ALIMENTOS; SELÊNIO; OBESIDADE
- Keywords: Epigenetics reprogramming; Fisiologia reprodutiva masculina; Male reproductive physiology; Obesidade; Obesity; Reprogramação epigenética; Selênio; Selenium
- Agências de fomento:
- Language: Inglês
- Abstract: Selenium (Se) role in obesity is not clear. In addition, information on Ses role in male physiology, specifically in obesity, is scarce. We conducted this study to evaluate the efficacy of Se supplementation, specifically during puberty until young adulthood, against obesity-induced deregulation of metabolic, cellular, and epigenetic parameters in epididymal fat and/or sperm cells in a rat model. High-fat-diet consumption by male rats during puberty and young adulthood significantly increased body weight, adipocyte size, oxidative stress, deregulated expression of genes associated with inflammation (Adiponectin, IL-6, TNF-α), adipogenesis (CEBPα), estrogen biosynthesis (CYP19) and epigenetic processes in epididymal adipose tissue (Dnmt3a), as well as altered microRNA expression vital for spermatogenesis in sperm cells (miR-15b and miR-497). On the other hand, Se supplementation significantly decreased oxidative stress and mitigated these molecular/epigenetic alterations in epididymal adipose tissue or sperm cells. Our results indicate that selenium supplementation during puberty/young adulthood could improve male physiology in the context of obesity. In addition, it suggests that Se could potentially positively affect offspring health
- Imprenta:
- Data da defesa: 08.07.2022
- Este periódico é de acesso aberto
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: gold
- Licença: cc-by-nc-sa
-
ABNT
PASCOAL, Gabriela de Freitas Laiber. Selenium supplementation during puberty and young adult-hood mitigates obesity-induced metabolic, cellular and epigenetic alterations in male rat physiology. 2022. Tese (Doutorado) – Universidade de São Paulo, São Paulo, 2022. Disponível em: https://www.teses.usp.br/teses/disponiveis/9/9132/tde-25082022-172904/. Acesso em: 27 abr. 2024. -
APA
Pascoal, G. de F. L. (2022). Selenium supplementation during puberty and young adult-hood mitigates obesity-induced metabolic, cellular and epigenetic alterations in male rat physiology (Tese (Doutorado). Universidade de São Paulo, São Paulo. Recuperado de https://www.teses.usp.br/teses/disponiveis/9/9132/tde-25082022-172904/ -
NLM
Pascoal G de FL. Selenium supplementation during puberty and young adult-hood mitigates obesity-induced metabolic, cellular and epigenetic alterations in male rat physiology [Internet]. 2022 ;[citado 2024 abr. 27 ] Available from: https://www.teses.usp.br/teses/disponiveis/9/9132/tde-25082022-172904/ -
Vancouver
Pascoal G de FL. Selenium supplementation during puberty and young adult-hood mitigates obesity-induced metabolic, cellular and epigenetic alterations in male rat physiology [Internet]. 2022 ;[citado 2024 abr. 27 ] Available from: https://www.teses.usp.br/teses/disponiveis/9/9132/tde-25082022-172904/ - Avaliação dos efeitos do consumo de dieta hiperlipídica à base de banha de porco em parâmetros metabólicos, de estresse oxidativo em ratos Sprague-Dawley machos
- Effect of paternal diet on spermatogenesis and offspring health: focus on epigenetics and interventions with food bioactive compounds
- Selenium supplementation during puberty and young adulthood mitigates obesity-induced metabolic, cellular and epigenetic alterations in male rat physiology
Informações sobre o DOI: 10.11606/T.9.2022.tde-25082022-172904 (Fonte: oaDOI API)
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