Neuropathological correlates of neuropsychiatric symptoms in dementia (2023)
- Authors:
- USP affiliated authors: FERRETTI-REBUSTINI, RENATA ELOAH DE LUCENA - EE ; PASQUALUCCI, CARLOS AUGUSTO GONCALVES - FM ; NITRINI, RICARDO - FM ; JACOB FILHO, WILSON - FM ; SUEMOTO, CLAUDIA KIMIE - FM
- Unidades: EE; FM
- Sigla do Departamento: ENC
- DOI: 10.1002/alz.12765
- Subjects: SINTOMAS PSÍQUICOS; DOENÇAS NEURODEGENERATIVAS
- Language: Inglês
- Abstract: Introduction Neuropsychiatric symptoms (NPS) are common in Lewy body disease (LBD), but their etiology is poorly understood. Methods In a population-based post mortem study neuropathological data was collected for Lewy body (LB) neuropathology, neurofibrillary tangles (NFT), amyloid beta burden, TDP-43, lacunar infarcts, cerebral amyloid angiopathy (CAA), and hyaline atherosclerosis. Post mortem interviews collected systematic information regarding NPS and cognitive status. A total of 1038 cases were included: no pathology (NP; n = 761), Alzheimer's disease (AD; n = 189), LBD (n = 60), and AD+LBD (n = 28). Results Hallucinations were associated with higher LB Braak stages, while higher NFT Braak staging was associated with depression, agitation, and greater number of symptoms in the Neuropsychiatric Inventory. Cases with dual AD+LBD pathology had the highest risk of hallucinations, agitation, apathy, and total symptoms but a multiplicative interaction between these pathologies was not significant. Discussion LB and AD pathology contribute differentially to NPS likely with an additive process contributing to the increased burden of NPS
- Imprenta:
- Source:
- Título do periódico: Alzheimer's & dementia: the journal of the Alzheimer's Association
- ISSN: 1552-5279
- Volume/Número/Paginação/Ano: v. 19, p. 1372-1382, 2023
- Este periódico é de assinatura
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: hybrid
- Licença: cc-by-nc-nd
-
ABNT
GIBSON, Lucy L et al. Neuropathological correlates of neuropsychiatric symptoms in dementia. Alzheimer's & dementia: the journal of the Alzheimer's Association, v. 19, p. 1372-1382, 2023Tradução . . Disponível em: https://doi.org/10.1002/alz.12765. Acesso em: 27 abr. 2024. -
APA
Gibson, L. L., Grinberg, L. T., ffytche, D., Leite, R. E. P., Rodriguez, R. D., Ferretti-Rebustini, R. E. de L., et al. (2023). Neuropathological correlates of neuropsychiatric symptoms in dementia. Alzheimer's & dementia: the journal of the Alzheimer's Association, 19, 1372-1382. doi:10.1002/alz.12765 -
NLM
Gibson LL, Grinberg LT, ffytche D, Leite REP, Rodriguez RD, Ferretti-Rebustini RE de L, Pasqualucci CAG, Nitrini R, Jacob Filho W, Aarsland D, Suemoto CK. Neuropathological correlates of neuropsychiatric symptoms in dementia [Internet]. Alzheimer's & dementia: the journal of the Alzheimer's Association. 2023 ; 19 1372-1382.[citado 2024 abr. 27 ] Available from: https://doi.org/10.1002/alz.12765 -
Vancouver
Gibson LL, Grinberg LT, ffytche D, Leite REP, Rodriguez RD, Ferretti-Rebustini RE de L, Pasqualucci CAG, Nitrini R, Jacob Filho W, Aarsland D, Suemoto CK. Neuropathological correlates of neuropsychiatric symptoms in dementia [Internet]. Alzheimer's & dementia: the journal of the Alzheimer's Association. 2023 ; 19 1372-1382.[citado 2024 abr. 27 ] Available from: https://doi.org/10.1002/alz.12765 - Direct Measurements of Abdominal Visceral Fat and Cognitive Impairment in Late Life: findings From an Autopsy Study
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Informações sobre o DOI: 10.1002/alz.12765 (Fonte: oaDOI API)
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