Trabalho de evento-resumo

Angiotensin-converting enzyme (ace) genetic background and nutritional environment: effects on experimental diabetes (2001)

• Autores:
  • Sterman Heimann, A
  • Abe, L K
  • Bentivoglio, M
• Autor USP: CHAVES, MARIA LUIZA MORAIS BARRETO DE - ICB
• Unidade: ICB
• Assunto: ANATOMIA
• Idioma: Inglês
• Resumo: Objetivo: To study some metabolic and cardiovascular phenotypes in diabetic genetically modified mice for the ACE gene. Métodos e Resultados: Three groups of male (C57BL/6J) mice with the following genotypes, wild (+/+), heterozygous (+/-), and insertional (+/++) for the ACE gene, were studied. Three-week-old mice were randomized into control (nondiabetic -ND) or diabetic groups (D). They were either fed with an atherogenic (AD) or a control diet (CD). At 7 weeks of age, streptozotocin (STZ-125mg/kg body weight-ip) was injected. Weekly tail-cuff blood pressure (BP), blood glucose (BG), body weight (BW), and chow consumption were measured from 7 (before diabetes) until 20 weeks of age when blood samples were collected for BG determination and the heart, aorta and kidneys were removed for hystological analysisResults: No differences were observed in BP and heart rate among all groups. D -+/++ mice had a higher mortality rate than +/+ and +/- mice. In ND+ CD animals, BG was higher in +/+ then in +/- mice. BG was higher in ND + AD mice with all genotypes. The +/- mice had the highest BG and the lowest BW among diabetics, fed with CD or AD. BW decrease was more critical in the +/- group fed with CD. In the ND mice, BW was not influenced by the diet. Diabetic animals fed with AD had a higher BG than in the group treated with CD. Conclusões: It was shown that this model is adequate for the study of diabetes pathophysiology. In this context, the extreme loss of BW inthe diabetics fed with CD is a metabolic characteristic of diabetic patients. Interestingly, it was also shown that despite of the highest BG and BW loss, +/- animals had the lowest mortality. This indicates that beside the metabolic environment, ACE genetic background is an important factor associated with mortality
• Imprenta:
  • Editora: Federação de Sociedades de Biologia Experimental
  • Local: Caxambu
  • Data de publicação: 2001
• Fonte:
  • Título do periódico: Resumos
• Nome do evento: Reunião Anual da Federação de Sociedades de Biologia Experimental - FeSBE

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• ABNT

  STERMAN HEIMANN, A et al. Angiotensin-converting enzyme (ace) genetic background and nutritional environment: effects on experimental diabetes. 2001, Anais.. Caxambu: Federação de Sociedades de Biologia Experimental, 2001. . Acesso em: 26 abr. 2024.

• APA

  Sterman Heimann, A., ,, Abe, L. K., & Bentivoglio, M. (2001). Angiotensin-converting enzyme (ace) genetic background and nutritional environment: effects on experimental diabetes. In Resumos. Caxambu: Federação de Sociedades de Biologia Experimental.

• NLM

  Sterman Heimann A, , Abe LK, Bentivoglio M. Angiotensin-converting enzyme (ace) genetic background and nutritional environment: effects on experimental diabetes. Resumos. 2001 ;[citado 2024 abr. 26 ]

• Vancouver

  Sterman Heimann A, , Abe LK, Bentivoglio M. Angiotensin-converting enzyme (ace) genetic background and nutritional environment: effects on experimental diabetes. Resumos. 2001 ;[citado 2024 abr. 26 ]

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