Mdm2 mRNA expression in salivary gland tumour cell lines (2004)
- Autores:
- Autores USP: MANTESSO, ANDREA - FO ; NUNES, FABIO DAUMAS - FO ; ARAUJO, VERA CAVALCANTI DE - FO
- Unidade: FO
- DOI: 10.1111/j.1600-0714.2004.00189.x
- Assuntos: GLÂNDULAS SALIVARES; PATOLOGIA BUCAL
- Idioma: Inglês
- Resumo: BACKGROUND: Murine double minute 2 (mdm2) is a cellular protooncogene, which, in conditions of overexpression or amplification, is capable of inactivating the functions of p53, leading to tumorigenesis. Immunoexpression of mdm2 in salivary gland tumours was previously found; however, it was necessary to find out if mdm2 was overexpressed. The aim of this study was to analyse the mRNA expression of mdm2 in salivary gland neoplasms and to correlate it to immunoexpression of p53 and p21 proteins. METHODS: Specimens of different salivary gland neoplasms were obtained from surgical resections, and cell lineages derived from these tissues were established. RNA extraction was performed and mRNA expression was investigated using reverse transcription-polymerase chain reaction (RT-PCR). Cellular expression of p53 and p21 proteins was investigated by immunofluorescence technique. RESULTS: Increased expression of mdm2 was found in the majority of cell lines analysed. CONCLUSIONS: Comparing all results, we postulated that overexpression of mdm2 is related to the tumorigenesis and/or tumour progression of salivary gland neoplasms
- Imprenta:
- Local: Copenhagen
- Data de publicação: 2004
- Fonte:
- Título do periódico: Journal Oral Pathology and Medicine
- Volume/Número/Paginação/Ano: v. 33, n. 2, p. 96-101, February 2004
- Este periódico é de assinatura
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: bronze
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ABNT
MANTESSO, Andrea et al. Mdm2 mRNA expression in salivary gland tumour cell lines. Journal Oral Pathology and Medicine, v. 33, n. 2, p. 96-101, 2004Tradução . . Disponível em: https://doi.org/10.1111/j.1600-0714.2004.00189.x. Acesso em: 17 abr. 2024. -
APA
Mantesso, A., Loducca, S. V. L., Bendit, I., Garicochea, B., Nunes, F. D., & Araújo, V. C. de. (2004). Mdm2 mRNA expression in salivary gland tumour cell lines. Journal Oral Pathology and Medicine, 33( 2), 96-101. doi:10.1111/j.1600-0714.2004.00189.x -
NLM
Mantesso A, Loducca SVL, Bendit I, Garicochea B, Nunes FD, Araújo VC de. Mdm2 mRNA expression in salivary gland tumour cell lines [Internet]. Journal Oral Pathology and Medicine. 2004 ; 33( 2): 96-101.[citado 2024 abr. 17 ] Available from: https://doi.org/10.1111/j.1600-0714.2004.00189.x -
Vancouver
Mantesso A, Loducca SVL, Bendit I, Garicochea B, Nunes FD, Araújo VC de. Mdm2 mRNA expression in salivary gland tumour cell lines [Internet]. Journal Oral Pathology and Medicine. 2004 ; 33( 2): 96-101.[citado 2024 abr. 17 ] Available from: https://doi.org/10.1111/j.1600-0714.2004.00189.x - WNT-5A, but not matrix metalloproteinase 3 or ß-catenin protein, expression is related to early stages pf lip carcinogenesis
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Informações sobre o DOI: 10.1111/j.1600-0714.2004.00189.x (Fonte: oaDOI API)
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