TGF'beta'1 role on induced hyperproliferation in gastric epithelium of suckling rats (2004)
- Autores:
- Autores USP: GAMA, PATRICIA - ICB ; ALVARES, ELIANA PARISI - ICB
- Unidade: ICB
- Assunto: HISTOLOGIA
- Idioma: Inglês
- Resumo: Endogenous and dietary factors affect the gastric epithelium growth in neonatal rats. Maternal milk is rich in hormones and growth factors such as the Transforming Growth Factor Beta (TGF'beta'), which plays a critical role on epithelial cell proliferation, differentiation, migration and apoptosis. To better understand the underlying mechanims of gastric response to TGF'beta', hyperproliferation was induced by fasting in 14-d-old suckling rats that were then treated with TGF'beta'1 (RD Systems 1ng/g bw) or saline (gavage or i.p.injection) 12h before sacrifice. Cell proliferation was assessed by pulse BrDU labeling (Sigma, 100 mg/Kg) and DNA synthetic index (SI%) obtention after cell counting. The stomachs were collected and processed also for the immunohistochemistry of the receptor T'beta'RII (Santa Cruz), Smad 2/3 (Upstate) and Smad 2P(Calbiochem), with peroxidase-DAB visualization. The preliminary results showed that TGF'beta'1 induced a reduction of cell proliferation (p<0,05) and altered the T'beta'RII-imunolabeling and the phosphorilation of Smad2 in treated rats when compared with the controls. These findings indicate that TGF'beta'1 has an inhibitory role on the hyperproliferative gastric epithelium of suckling rats and that high levels of this growth factor in the stomach may upregulate T'beta'RII and the signaling cascade
- Imprenta:
- Fonte:
- Título do periódico: Abstracts
- Nome do evento: Congress of the Brazilian Society for Cell Biology
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ABNT
SÁ, Eunice R. A. et al. TGF'beta'1 role on induced hyperproliferation in gastric epithelium of suckling rats. 2004, Anais.. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2004. . Acesso em: 23 abr. 2024. -
APA
Sá, E. R. A., Ogias, D., Bittencourt, B., Alvares, E. P., & Gama, P. (2004). TGF'beta'1 role on induced hyperproliferation in gastric epithelium of suckling rats. In Abstracts. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
Sá ERA, Ogias D, Bittencourt B, Alvares EP, Gama P. TGF'beta'1 role on induced hyperproliferation in gastric epithelium of suckling rats. Abstracts. 2004 ;[citado 2024 abr. 23 ] -
Vancouver
Sá ERA, Ogias D, Bittencourt B, Alvares EP, Gama P. TGF'beta'1 role on induced hyperproliferation in gastric epithelium of suckling rats. Abstracts. 2004 ;[citado 2024 abr. 23 ] - Myenteric ablation increases the area of vip submucous neurons in weanling rats
- Efeitos da desnutrição protéica materna na proliferação celular dos epitélios digestórios de ratos lactentes
- Expressão e distribuição dos fatores de crescimento rtansformante beta 1 e 2 no epitélio do estômago de ratos durante o desenvolvimento
- Myenteric ablation increases the area of vip submucous neurons in weanling rats
- Expression of transforming growth factor 'alfa' in gastric epithelium of sialoadenectomized suckling rats submitted to fasting
- Expression of TGF'beta' and receptors in gastric mucosa of suckling rats: effects of hydrocortisone and dietary manipulation
- Maternal protein malnutrition effects on cell proliferation and growth factors expression in the gastrointestinal epithelium of suckling rats
- A restrição protéica durante o desenvolvimento do rato reduz a proliferação no estômago e aumenta os níveis de ghrelina gástrica
- In vivo effects of TGF'beta'1 on the growth of gastric epithelium in suckling rats
- Submandibular glands and the regulation of gastric proliferation and TGFα distribution during rat postnatal development
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