Hyperhomocysteinemia enhances the endothelin-1-induced contractions of rat carotid artery: role of ETA and ETB receptors (2005)
- Authors:
- USP affiliated authors: PASSAGLIA, RITA DE CASSIA ALEIXO TOSTES - ICB ; IYOMASA, MAMIE MIZUSAKI - FORP ; OLIVEIRA, ANA MARIA DE - FCFRP
- Unidades: ICB; FORP; FCFRP
- Assunto: FARMACOLOGIA
- Language: Português
- Abstract: Objetivo: One of the mechanisms by which hyperhomocysteinemia (HHcy) has been described to interfere the vascular reactivity is decreasing the synthesis of ET-1, which could be related to alterations on vascular reactivity for this agonist. We aimed to investigate the consequence of HHcy on the contraction induced by endothelin-1 (ET- 1), on rat carotid artery and the mechanisms involved in this response. Métodos e Resultados: Adult male Wistar rats were divided into Control (received water) and HHcy (received a solution of DL-Hcy thiolactone 1g/kg/day during 15 days) groups. The rats were sacrificed at the end of 15 days. The carotid artery was removed and placed in an organ chamber. HHcy induced an enhancement in the maximal effect (Emax:g/mg tissue) for ET-1 after 15 days. BQ123, an ETA receptor antagonist, and BQ788, an ETB receptor antagonist, decreased the ET-1 Emax in control and more pronounced in HHcy group. The mRNA and protein expression for ET-1, ETA and ETB receptors, and the releasing of ET-1 were similar for 2 groups. Conclusions: The enhanced ET-1 Emax evoked by HHcy in carotid arteries involves different pathways; these include an enhancement on the ET-1 affinity by ET receptors, enhancement on the Ca2+ influx and a reduction on the relaxation induced by activation of endothelial ETB receptors
- Imprenta:
- Publisher: Federação de Sociedades de Biologia Experimental
- Publisher place: Águas de Lindóia
- Date published: 2005
- Source:
- Título do periódico: Resumos
- Conference titles: Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE
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ABNT
ANDRADE, C. R et al. Hyperhomocysteinemia enhances the endothelin-1-induced contractions of rat carotid artery: role of ETA and ETB receptors. 2005, Anais.. Águas de Lindóia: Federação de Sociedades de Biologia Experimental, 2005. . Acesso em: 24 abr. 2024. -
APA
Andrade, C. R., Passaglia, R. de C. A. T., Casolari, D. A., Yogi, A., Montezano, A. C. I., Iyomasa, M. M., & Oliveira, A. M. de. (2005). Hyperhomocysteinemia enhances the endothelin-1-induced contractions of rat carotid artery: role of ETA and ETB receptors. In Resumos. Águas de Lindóia: Federação de Sociedades de Biologia Experimental. -
NLM
Andrade CR, Passaglia R de CAT, Casolari DA, Yogi A, Montezano ACI, Iyomasa MM, Oliveira AM de. Hyperhomocysteinemia enhances the endothelin-1-induced contractions of rat carotid artery: role of ETA and ETB receptors. Resumos. 2005 ;[citado 2024 abr. 24 ] -
Vancouver
Andrade CR, Passaglia R de CAT, Casolari DA, Yogi A, Montezano ACI, Iyomasa MM, Oliveira AM de. Hyperhomocysteinemia enhances the endothelin-1-induced contractions of rat carotid artery: role of ETA and ETB receptors. Resumos. 2005 ;[citado 2024 abr. 24 ] - The adipokine chemerin augments the constrictor effects of ET-1 and phenylephrine in rat aorta
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