Artigo de periodico

Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice (2008)

• Authors:
  • Miranda, Daniel D. C
  • Arçari, Demetrius P.
  • Pedrazzolli Jr, José
  • Carvalho, Patrícia de Oliveira
  • Cerutti, Suzete M
  • Bastos, Deborah Helena Markowicz
  • Ribeiro, Marcelo L
• Autor USP: BASTOS, DEBORAH HELENA MARKOWICZ - FSP
• Unidade: FSP
• DOI: 10.1093/mutage/gen011
• Subjects: MATE (PROPRIEDADES); ANTIOXIDANTES (ATIVIDADE); BIOLOGIA MOLECULAR; GENÉTICA MOLECULAR; REPARAÇÃO DE DNA; RATOS
• Language: Inglês
• Abstract: Yerba mate (Ilex paraguariensis) is rich in several bioactive compounds that can act as free radical scavengers. Since oxidative DNA damage is involved in various pathological states such as cancer, the aim of this study was to evaluate the antioxidant activity of mate tea as well as the ability to influence DNA repair in male Swiss mice. Forty animals were randomly assigned to four groups. The animals received three different doses of mate tea aqueous extract, 0.5, 1.0 or 2.0 g/kg, for 60 days. After intervention, the liver, kidney and bladder cells were isolated and the DNA damage induced by H2O2 was investigated by the comet assay. The DNA repair process was also investigated for its potential to protect the cells from damage by the same methodology. The data presented here show that mate tea is not genotoxic in liver, kidney and bladder cells. The regular ingestion of mate tea increased the resistance of DNA to H2O2-induced DNA strand breaks and improved the DNA repair after H2O2 challenge in liver cells, irrespective of the dose ingested. These results suggest that mate tea could protect against DNA damage and enhance the DNA repair activity. Protection may be afforded by the antioxidant activity of the mate tea's bioactive compounds
• Imprenta:
  • Publisher place: Oxford
  • Date published: 2008
• Source:
  • Título do periódico: Mutagenesis
  • Volume/Número/Paginação/Ano: v. 23, n. 4, p. 261-265, 2008

Informações sobre o DOI: 10.1093/mutage/gen011 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo é de acesso aberto
• URL de acesso aberto
• Cor do Acesso Aberto: bronze

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How to cite

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• ABNT

  MIRANDA, Daniel D. C et al. Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice. Mutagenesis, v. 23, n. 4, p. 261-265, 2008Tradução . . Disponível em: https://doi.org/10.1093/mutage/gen011. Acesso em: 05 maio 2024.

• APA

  Miranda, D. D. C., Arçari, D. P., Pedrazzolli Jr, J., Carvalho, P. de O., Cerutti, S. M., Bastos, D. H. M., & Ribeiro, M. L. (2008). Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice. Mutagenesis, 23( 4), 261-265. doi:10.1093/mutage/gen011

• NLM

  Miranda DDC, Arçari DP, Pedrazzolli Jr J, Carvalho P de O, Cerutti SM, Bastos DHM, Ribeiro ML. Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice [Internet]. Mutagenesis. 2008 ; 23( 4): 261-265.[citado 2024 maio 05 ] Available from: https://doi.org/10.1093/mutage/gen011

• Vancouver

  Miranda DDC, Arçari DP, Pedrazzolli Jr J, Carvalho P de O, Cerutti SM, Bastos DHM, Ribeiro ML. Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice [Internet]. Mutagenesis. 2008 ; 23( 4): 261-265.[citado 2024 maio 05 ] Available from: https://doi.org/10.1093/mutage/gen011

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