Dentin-induced in vivo inflammatory response and in vitro activation of murine macrophages (2003)
- USP affiliated authors: LARA, VANESSA SOARES - FOB ; CUNHA, FERNANDO DE QUEIROZ - FMRP
- USP Schools: FOB; FMRP
- Subjects: ÓXIDO NÍTRICO; CÉLULAS; RAIZ DENTÁRIA
- Language: Inglês
- Abstract: The activation of inflammatory cells and consequent release of mediators play an important role in the resorption of mineralized tissues. In the present study, we examined the ability of dentin extracts to induce inflammatory cell recruitment and activation. We showed here that dentin extracts triggered an intense cell migration and progressive cell maturation, in a time and dose dependent manner. Expression of interleukin-1 'beta' (IL-1'beta'), tumor necrosis factor-'alfa' (TNF-'alfa'), nitric oxide (NO), and hydrogen peroxide ('H IND.2''O IND.2') was also up-regulated by dentin extracts. These results show that inflammatory events can be elicited in response to dentin, which may suggest a possible involvement of dentin molecules in the inflammatory events, coupled with their release at the root resorption sites
Título: Journal of Dental Research
Citescore - 2017: 5.05
SJR - 2017: 2.302
SNIP - 2017: 2.096
ABNTLARA, Vanessa Soares; FIGUEIREDO, F.; SILVA, T. A. da; CUNHA, Fernando de Queiroz. Dentin-induced in vivo inflammatory response and in vitro activation of murine macrophages. Journal of dental research, Chicago, v. 82, n. 6, p. 460-465, 2003.
APALara, V. S., Figueiredo, F., Silva, T. A. da, & Cunha, F. de Q. (2003). Dentin-induced in vivo inflammatory response and in vitro activation of murine macrophages. Journal of dental research, 82( 6), 460-465.
NLMLara VS, Figueiredo F, Silva TA da, Cunha F de Q. Dentin-induced in vivo inflammatory response and in vitro activation of murine macrophages. Journal of dental research. 2003 ; 82( 6): 460-465.
VancouverLara VS, Figueiredo F, Silva TA da, Cunha F de Q. Dentin-induced in vivo inflammatory response and in vitro activation of murine macrophages. Journal of dental research. 2003 ; 82( 6): 460-465.
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