High molecular weight components from ascaris suum suppress immune response to an unrelated antigen through IL-4 and IL-10 cytokines (2003)
- Authors:
- Autor USP: MACEDO, MAHASTI SAHIHI DE - ICB
- Unidade: ICB
- Assunto: IMUNOLOGIA
- Language: Português
- Abstract: Aims: The extract from Ascaris suum worms (Asc) stimulates a Th2-type response and impairs the immune response to ovalbumin (OA) in mice. IL-4/IL-10 cytokines are involved in the suppressive effect of Asc, because treatment of OA+Asc-immunized DBA/2 mice with anti-IL-4+anti-IL-10 mAb abolished the suppression of OA-specific Th1-related parameters. PI (high MW proteins from Asc), which are responsible for the suppressive effect, elicited IL-4/IL-10 production in large quantities. In contrast, PIII (low MW proteins), that stimulates IgE antibodies, induced a Th0-type response. Thus, we decided to work with PI apart from PIII to investigate the real participation of PI-induced IL-4/IL-10 in down-regulation of Th1/Th2 responses to OA. Materials: IL-10-/- mice, IL-4-/- mice treated with anti-IL-10 mAb or wild-type mice were immunized with OA or OA+PI in adjuvant.Eight days later, we compared the immediate and delayed-type hypersensitivity reactions (HRs) in these mice when challenged in the footpad with aggregated OA, the levels of OA-induced antibodies and IFN-gamma/IL-2 cytokines productionIn the absence of IL-10, the suppressive effect of PI on the HRs to OA was abolished. Total recovery of IFN-gamma/IL-2 levels in OA+PI-immunized mice was only obtained in the simultaneous absence of IL-10/IL-4. The suppression of OA-specific Ab prodproduction was also reduced in IL-10-/- mice (IgG1/IgE) and in IL-10-deficient, IL-4-/- mice (IgG2c). CONCLUSIONS: These results indicate that IL-10 is involved in the suppression of OA-specific Th2-related parameters by Ascaris high MW componentcomponents, while IL-4/IL-10 act together in the suppression of Th1 parameters.
- Imprenta:
- Publisher: Comissão de Pesquisa do ICB/USP
- Publisher place: São Paulo
- Date published: 2003
- Source:
- Título do periódico: Resumos
- Conference titles: Congresso Instituto Ciências Biomédicas, IV
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ABNT
SOUZA, Valdênia Maria Oliveira e MACEDO, Mahasti Sahihi de. High molecular weight components from ascaris suum suppress immune response to an unrelated antigen through IL-4 and IL-10 cytokines. 2003, Anais.. São Paulo: Comissão de Pesquisa do ICB/USP, 2003. . Acesso em: 19 abr. 2024. -
APA
Souza, V. M. O., & Macedo, M. S. de. (2003). High molecular weight components from ascaris suum suppress immune response to an unrelated antigen through IL-4 and IL-10 cytokines. In Resumos. São Paulo: Comissão de Pesquisa do ICB/USP. -
NLM
Souza VMO, Macedo MS de. High molecular weight components from ascaris suum suppress immune response to an unrelated antigen through IL-4 and IL-10 cytokines. Resumos. 2003 ;[citado 2024 abr. 19 ] -
Vancouver
Souza VMO, Macedo MS de. High molecular weight components from ascaris suum suppress immune response to an unrelated antigen through IL-4 and IL-10 cytokines. Resumos. 2003 ;[citado 2024 abr. 19 ] - Supressive and stimulation activities of Ascaris suum extract on ige antibody responses
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- Modulation of anaphylatic and non-anaphylatic IgG1 antibody production by ajuvants
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- Th2-type cells regulate delayed-type hypersensitivity reactions elicited shortly after immunization
- Ascaris suum extract inhibits pulmonary eosinophilic hypersensitivity in mice: effect on chemokine production and on bone marrow
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