Experimental study of the interference of dissodium phosphate of dexamethasone in the process of rat tibia bone repair (2002)
- Authors:
- Autor USP: SOTTOVIA FILHO, DAGOBERTO - FOB
- Unidade: FOB
- Subjects: OSSO E OSSOS; OSSEOINTEGRAÇÃO
- Language: Inglês
- Abstract: The present research assessed the interface of dexamethasone in the bone repair process in surgical wounds produced in rat tibia. The rats used as sample were divided in three groups. In all groups two monocortical perforations were produced in the tibia's diaphysis. The material was collected and processed for histological analysis, in period of 24 and 48 hours, 7 and 21 days, after surgical stage. The control group did not get intra muscular dexamethasone shots. One groups received a dosage of 0.1mL solution of 8mg dexamethasone by 5mL of saline an hour prior to surgical procedures. The third group received one hour prior to the surgery and continued receiving the same dosage for three days after the surgery, every 8 hours. The comparative histological analysis of the repairing processes showed that, in the control group and in the group that received only one pre-surgical dosage, the repair of the perforations was determined on the twenty-first day. There was evident delay in the repairing process in the group that received one pre-surgical dosage and continued receiving it during the entire experimental period. On the twenty-first day after the surgery, a granulation tissue was still possible to be observed, and it was intermidiated by an osseous blastema. Coagulum remnants were observed and the periosteum was not fully repaired. This remarks show a clear delay in the healing that will heve to be taken into account at the moment of prescribing steroidalanti-inflamatory medicines when only the facial edema decrease is desired
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ABNT
SOTTOVIA, André Dotto et al. Experimental study of the interference of dissodium phosphate of dexamethasone in the process of rat tibia bone repair. Salusvita, v. 21, n. 1, p. 23-33, 2002Tradução . . Acesso em: 26 abr. 2024. -
APA
Sottovia, A. D., Gonçalves, E. S., Sottovia Filho, D., & Iala, C. B. (2002). Experimental study of the interference of dissodium phosphate of dexamethasone in the process of rat tibia bone repair. Salusvita, 21( 1), 23-33. -
NLM
Sottovia AD, Gonçalves ES, Sottovia Filho D, Iala CB. Experimental study of the interference of dissodium phosphate of dexamethasone in the process of rat tibia bone repair. Salusvita. 2002 ; 21( 1): 23-33.[citado 2024 abr. 26 ] -
Vancouver
Sottovia AD, Gonçalves ES, Sottovia Filho D, Iala CB. Experimental study of the interference of dissodium phosphate of dexamethasone in the process of rat tibia bone repair. Salusvita. 2002 ; 21( 1): 23-33.[citado 2024 abr. 26 ] - Estudo morfométrico da população de mastócitos na gengiva humana normal e inflamada
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