Expression of integrin subunits ´alfa´2, ´alfa´3, ´alfa´5, ´alfa´v, ´beta´1, ´beta´3 and ´beta´4 in different histological types of ameloblastoma compared with dental germ, dental lamina and adult lining epithelium (2004)
- Authors:
- USP affiliated authors: MARTINS, MARILIA TRIERVEILER - FO ; ARAUJO, VERA CAVALCANTI DE - FO
- Unidade: FO
- Subjects: INTEGRINAS; AMELOBLASTOMA; GERME DE DENTE; IMUNOHISTOQUÍMICA
- Language: Inglês
- Abstract: OBJECTIVE: To analyze integrin expression and distribution in different histological types of ameloblastoma, compared with dental germ, dental lamina and adult lining epithelium. MATERIALS AND METHODS: Three-micrometer sections from paraffin-embedded specimens were evaluated employing a streptavidin-biotin immunohistochemical method and anti-integrin ´alfa´2, ´alfa´3, ´alafa´5, ´alfa´v, ´beta´1, ´beta´3 and ´beta´4 antibodies. RESULTS: All integrins were present in all specimens, exhibiting different patterns. In follicular ameloblastoma, the integrin staining was stronger in the periphery while integrin ´alfa´2 was not present in the central cells. Acanthomatous ameloblastoma showed a similar pattern, with positive staining for integrins ´alfa´3, ´alfa´5, ´alfa´v, ´beta´1 and ´beta´4 in the metaplastic cells. In the unicystic, integrin staining was uniform except for integrins ´alfa´5 and ´beta´3 which showed weaker staining in the upper layers. In the plexiform ameloblastoma, dental germ and lamina integrin staining was uniform. In the adult lining epithelium, staining for integrins ´alfa´2, ´alfa´5 and ´beta´4 was confined to the basal layer, while integrins ´alfa´v and ´beta´3 were present in the basal and parabasal, with integrins ´alfa´3 and ´beta´1 in the upper layers. CONCLUSION: Acanthomatous, follicular and unicystic ameloblastomas showed integrin staining patterns similar to the adult lining epithelium while the plexiformameloblastoma was similar to the dental germ and lamina
- Imprenta:
- Source:
- Título do periódico: Oral Diseases
- ISSN: 1354-523X
- Volume/Número/Paginação/Ano: v. 10, n. 5, p.277-282, September 2004
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ABNT
MODOLO, F. et al. Expression of integrin subunits ´alfa´2, ´alfa´3, ´alfa´5, ´alfa´v, ´beta´1, ´beta´3 and ´beta´4 in different histological types of ameloblastoma compared with dental germ, dental lamina and adult lining epithelium. Oral Diseases, v. 10, n. 5, p. 277-282, 2004Tradução . . Acesso em: 19 abr. 2024. -
APA
Modolo, F., Loducca, S. V. L., Martins, M. T., & Araújo, V. C. de. (2004). Expression of integrin subunits ´alfa´2, ´alfa´3, ´alfa´5, ´alfa´v, ´beta´1, ´beta´3 and ´beta´4 in different histological types of ameloblastoma compared with dental germ, dental lamina and adult lining epithelium. Oral Diseases, 10( 5), 277-282. -
NLM
Modolo F, Loducca SVL, Martins MT, Araújo VC de. Expression of integrin subunits ´alfa´2, ´alfa´3, ´alfa´5, ´alfa´v, ´beta´1, ´beta´3 and ´beta´4 in different histological types of ameloblastoma compared with dental germ, dental lamina and adult lining epithelium. Oral Diseases. 2004 ; 10( 5): 277-282.[citado 2024 abr. 19 ] -
Vancouver
Modolo F, Loducca SVL, Martins MT, Araújo VC de. Expression of integrin subunits ´alfa´2, ´alfa´3, ´alfa´5, ´alfa´v, ´beta´1, ´beta´3 and ´beta´4 in different histological types of ameloblastoma compared with dental germ, dental lamina and adult lining epithelium. Oral Diseases. 2004 ; 10( 5): 277-282.[citado 2024 abr. 19 ] - Maspin expression in normal and neoplastic salivary gland
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