Expression of TGF'beta' and receptors in gastric mucosa of suckling rats: effects of hydrocortisone and dietary manipulation (2004)
- Authors:
- USP affiliated authors: ALVARES, ELIANA PARISI - ICB ; GAMA, PATRICIA - ICB
- Unidade: ICB
- Assunto: HISTOLOGIA
- Language: Inglês
- Abstract: Cell proliferation in gastric epithelium may be inhibited during postnatal development under different conditions as dietary manipulation and glucocorticoid treatment. The transforming growth factor beta (TGF?) can mediate these inhibitory responses, our aim was to evaluate the immunistaining for TGF?1, 2, 3 and recptors T?RI and T?RII in the gastric mucosa of 18-day-old pups using the early weaning model for diet manipulation and hydrocortisone treatment for hormonal induction. Rats were subjected to early weaning on the 15th day, to fasting on the 17th and sacrificed at 18 days. For hormonal treatment 18-day-old pups were injected i.p. with hydrocortisone (Sigma, 50 mg/kg) and sacrificed after 0, 1 and 3 hours. The stomachs were collected and processed for immunohistochemistry. Early weaning followed by fasting increased the number of TGF?3 and T?RI immunolabelled cells (p<0,05). After 3 hs of hydrocortisone treatment there was an increase in TGF?1 immunostaining (p<0,05) and a decrease of TGF?2 labelled cells (p<0,05). We can suggest that the upregulation of specific TGF? isoforms in the gastric epithelium after abrupt dietary change or hydrocortisone treatment, may be correlated to the inhibition of cell proliferation in the stomach during development
- Imprenta:
- Source:
- Título do periódico: Abstracts
- Conference titles: Congress of the Brazilian Society for Cell Biology
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ABNT
OGIAS, Daniela et al. Expression of TGF'beta' and receptors in gastric mucosa of suckling rats: effects of hydrocortisone and dietary manipulation. 2004, Anais.. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2004. . Acesso em: 18 mar. 2024. -
APA
Ogias, D., Bittencourt, B., Sá, E. R. A., Osaki, L. H., Nishitokukado, I., Alvares, E. P., & Gama, P. (2004). Expression of TGF'beta' and receptors in gastric mucosa of suckling rats: effects of hydrocortisone and dietary manipulation. In Abstracts. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
Ogias D, Bittencourt B, Sá ERA, Osaki LH, Nishitokukado I, Alvares EP, Gama P. Expression of TGF'beta' and receptors in gastric mucosa of suckling rats: effects of hydrocortisone and dietary manipulation. Abstracts. 2004 ;[citado 2024 mar. 18 ] -
Vancouver
Ogias D, Bittencourt B, Sá ERA, Osaki LH, Nishitokukado I, Alvares EP, Gama P. Expression of TGF'beta' and receptors in gastric mucosa of suckling rats: effects of hydrocortisone and dietary manipulation. Abstracts. 2004 ;[citado 2024 mar. 18 ] - Differential expression of transforming growth factor beta in the stomach of rats during development
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