Chronic circadian desynchronization decreases the survival of NZB/W(F1) mice (2005)
- Authors:
- Autor USP: BARRETO, LUIZ SILVEIRA MENNA - ICB
- Unidade: ICB
- Assunto: FISIOLOGIA
- Language: Inglês
- Abstract: Introduction: It is generally accepted that organisms derive benefits from the temporal organization of their physiology and behavior. Life expectancy may be reduced for some organisms raised under light-dark (LD) cycles with periods that differ substantially from that of their known circadian rhythm as well as for animals submitted to repeated phase shifts in the LD cycle. Objective: This study assessed the influence of chronic circadian desynchronization on the development of proteinuria and life span in NZB/W (F1) lupus prone mice. Methods: After the weaning, animals were housed in polypropylene cages with food and water freely available and were divided into two groups: experimental and control. The control one maintained on a fixed 12:12h LD cycle, and the experimental was subjected to a 12h phase shift in the LD cycle on a weekly basis. Urinary protein levels were monitored weekly by the use of reagent strips and the duration of life span was recorded for each animal.Results: Chronic reversal of the external LD cycle at weekly intervals resulted in a significant decrease in the survival time in NZB/W(F1) mice, with the median life span being reduced by 21%. Moreover, Student t-test showed significant statistical difference in the interval between the detection of proteinuria and death (p<0,05), and the vatiation coefficient demonstrated greater variability of this interval within the experimental group. Conclusion: Disruptingordinary circadian rhythmicity in animals susceptible to early mortality due to autoimmune disease results in further decrease in longevity.
- Imprenta:
- Publisher: Comissão de Cultura e Extensão Universitária do ICB/USP
- Publisher place: São Paulo
- Date published: 2005
- Source:
- Título do periódico: Resumos
- Conference titles: Congresso do Instituto de Ciências Biomédicas
-
ABNT
MIGUEL, M. L. et al. Chronic circadian desynchronization decreases the survival of NZB/W(F1) mice. 2005, Anais.. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP, 2005. . Acesso em: 19 abr. 2024. -
APA
Miguel, M. L., Costa-Pinto, F. A., Lopes, J. R., & Menna-Barreto, L. S. (2005). Chronic circadian desynchronization decreases the survival of NZB/W(F1) mice. In Resumos. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP. -
NLM
Miguel ML, Costa-Pinto FA, Lopes JR, Menna-Barreto LS. Chronic circadian desynchronization decreases the survival of NZB/W(F1) mice. Resumos. 2005 ;[citado 2024 abr. 19 ] -
Vancouver
Miguel ML, Costa-Pinto FA, Lopes JR, Menna-Barreto LS. Chronic circadian desynchronization decreases the survival of NZB/W(F1) mice. Resumos. 2005 ;[citado 2024 abr. 19 ] - School schedule transition and adolescent's biological rhythms
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