Endothelin type A receptor regulates lymphocyte infiltration in murine asthma (2006)
- USP affiliated authors: NEGRO, SONIA JANCAR - ICB ; LANDGRAF, RICHARDT GAMA - ICB
- USP Schools: ICB; ICB
- Subjects: IMUNOLOGIA
- Language: Inglês
- Abstract: Introduction and Objectives: Asthma is a complex disease characterized by a specific pattern of inflammation in the airways, involving eosinophils and lymphocytes with prevalence of the Th2 sub-type with some reports suggesting involvement of NK1.1, Tãä, and CD8 cells as well. The inflammatory response in asthma derives from activation of these cells and of endothelium leading to airways obstruction with mucus and constriction. Endothelial cells produce a family of peptides with named endothelins. Although elevated levels of endothelin were detected in the bronchoalveolar lavage of patients during asthma attacks, its role in asthma is not known. In this study, we examined the effect of endothelin-A and B receptor antagonists on lymphocyte and eosinophil infiltration, mucus production and bronchial hyperreactivity. Methods and Results: Mice C57Bl/6 were immunized with OVA/alumen (10µg/1.6 mg, i.p.), and challenged 14 and 21 days later by exposure to OVA aerosol (2,5%, 20min). Endothelin-A (BQ123) and endothelin-B (BQ788) receptor antagonists (1mg/kg) were given i.p. 30 min before each challenge, to OVA sensitized mice.hyperreactivity (21%) and mucus production (52%), but strongly increased CD4 (872%), CD8 (366%), NK1.1 (650%) and Tãä (83%) cell numbers. Pre-treatment with equimolar concentration of BQ788 did not significantly affect these parameters. Conclusion: These results show that endothelins, acting via endothelin-A receptor, increases lymphocyte infiltration in murine asthma and down regulates eosinophils infiltration, mucus production and airways hyperreactivity.
- Título do periódico: Abstracts
- Conference titles: Meeting of the Brazilian Society for Immunology
ABNTLANDGRAF, Richardt Gama; JANCAR, Sonia. Endothelin type A receptor regulates lymphocyte infiltration in murine asthma. Anais.. São Paulo: [s.n.], 2006.
APALandgraf, R. G., & Jancar, S. (2006). Endothelin type A receptor regulates lymphocyte infiltration in murine asthma. In Abstracts. São Paulo.
NLMLandgraf RG, Jancar S. Endothelin type A receptor regulates lymphocyte infiltration in murine asthma. Abstracts. 2006 ;
VancouverLandgraf RG, Jancar S. Endothelin type A receptor regulates lymphocyte infiltration in murine asthma. Abstracts. 2006 ;
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