Participation of B-1 cells in the rejection of allogeneic grafts in mice (2006)
- Authors:
- Autor USP: MARIANO, MARIO - ICB
- Unidade: ICB
- Assunto: IMUNOLOGIA
- Language: Inglês
- Abstract: Introduction and Objectives: The ontogeny and functions of B-1 cells in the immune system are still unclear. B-1 cells differ from classic B lymphocytes (B-2) in many aspects: tissue distribution, surface markers, development pathways and antibody repertoire. It has recently been described that B-1 cells have an important role in reactions classically known to be T-cell mediated (J. Immunol. 175:7170-8, 2005). Although the chronic rejection of allogeneic grafts is also considered to be mainly a T-cell mediated immunity, other cell types certainly contribute to the elimination of the foreign tissue. Our objective was to assess whether B-1 cells are involved in the rejection of allogeneic grafts in mice. Methods and Results: Two transplantation techniques were performed using C57BL/6 mice as donors and BALB/c or BALB/Xid mice as receptors: (i) Newborn split-hearts were placed in a subcutaneous pocket made in the receptor's ear pinna and (ii) a 1 cm2 skin piece from the receptor's tail was transplanted to the dorsal region of the donor. In both cases, animals were daily monitored until the day of rejection, which was defined when the implant could no more be visualized.Survival curves of heart-grafted BALB/c (n=7) and BALB/Xid (n=7) showed a significant (p=0,0031) delay in the rejection date in the BALB/Xid group. However, when BALB/Xid mice were reconstituted with a B-1 cell-enriched suspension (80% purity), the rejection datesbetween BALB/Xid (n=9) and BALB/c (n=8) exhibited no difference (p=0,7331). Survival curves of skin-grafted BALB/c (n=5) and BALB/Xid (n=10) also showed a delay in the rejection date in BALB/Xid mice (p=0,0424). Conclusion: These data indicate that B-1 cells participate in the allogeneic graft rejection process in mice and their absence retards the elimination of the heterologous tissue.
- Imprenta:
- Source:
- Título do periódico: Abstracts
- Conference titles: Meeting of the Brazilian Society for Immunology
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ABNT
NOGUEIRA-MARTINS, M F e MARIANO, Mário. Participation of B-1 cells in the rejection of allogeneic grafts in mice. 2006, Anais.. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2006. . Acesso em: 26 abr. 2024. -
APA
Nogueira-Martins, M. F., & Mariano, M. (2006). Participation of B-1 cells in the rejection of allogeneic grafts in mice. In Abstracts. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
Nogueira-Martins MF, Mariano M. Participation of B-1 cells in the rejection of allogeneic grafts in mice. Abstracts. 2006 ;[citado 2024 abr. 26 ] -
Vancouver
Nogueira-Martins MF, Mariano M. Participation of B-1 cells in the rejection of allogeneic grafts in mice. Abstracts. 2006 ;[citado 2024 abr. 26 ] - Morphological aspects of free floating schistosoma egg granulomata in the peritoneal cavity of infected mice
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