Prospective study of hepatitis C virus infection in hemodialysis patients by monthly analysis of HCV RNA and antibodies (2003)
- Authors:
- Autor USP: CARDOSO, MARIA REGINA ALVES - FSP
- Unidade: FSP
- DOI: 10.1139/w03-065
- Subjects: HEPATITE C; TERAPIA DE SUBSTITUIÇÃO RENAL; REAÇÃO EM CADEIA POR POLIMERASE; VÍRUS DA HEPATITE C (GENÉTICA)
- Language: Inglês
- Abstract: Abstract: The aims of this study were to (i) evaluate the prevalence and the incidence of hepatitis C virus (HCV) infection in hemodialysis patients in two different centers in São Paulo (Brazil), (ii) determine the time required to detect HCV infection among these patients by serology or PCR, (iii) establish the importance of alanine aminotransferase determination as a marker of HCV infection, and (iv) identify the HCV genotypes in this population. Serum samples were collected monthly for 1 year from 281 patients admitted to hospital for hemodialysis. Out of 281 patients, 41 patients (14.6 percent) were HCV positive; six patients seroconverted during this study (incidence=3.1/1000 person-month). In 1.8 percent (5/281) of cases, RNA was detected before the appearance of antibodies (up to 5 months), and in 1.1 percent (3/281) of cases, RNA was the unique marker of HCV infection. The genotypes found were 1a, 1b, 3a, and 4a. The presence of genotype 4a is noteworthy, since it is a rare genotype in Brazil. These data pointed out the high prevalence and incidence of HCV infection at hemodialysis centers in Brazil and showed that routine PCR is fundamental for improving the detection of HCV carriers among patients undergoing hemodialysis
- Imprenta:
- Source:
- Título do periódico: Canadian Journal of Microbiology
- ISSN: 1480-3275
- Volume/Número/Paginação/Ano: v. 49, n. 8, p. 503-507, 2003
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
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ABNT
PINHO, João Renato Rebello et al. Prospective study of hepatitis C virus infection in hemodialysis patients by monthly analysis of HCV RNA and antibodies. Canadian Journal of Microbiology, v. 49, n. 8, p. 503-507, 2003Tradução . . Disponível em: https://doi.org/10.1139/w03-065. Acesso em: 24 abr. 2024. -
APA
Pinho, J. R. R., Fares, J. A., Oba, I. T., Cardoso, M. R. A., Saraceni, C. P., & Granato, C. (2003). Prospective study of hepatitis C virus infection in hemodialysis patients by monthly analysis of HCV RNA and antibodies. Canadian Journal of Microbiology, 49( 8), 503-507. doi:10.1139/w03-065 -
NLM
Pinho JRR, Fares JA, Oba IT, Cardoso MRA, Saraceni CP, Granato C. Prospective study of hepatitis C virus infection in hemodialysis patients by monthly analysis of HCV RNA and antibodies [Internet]. Canadian Journal of Microbiology. 2003 ; 49( 8): 503-507.[citado 2024 abr. 24 ] Available from: https://doi.org/10.1139/w03-065 -
Vancouver
Pinho JRR, Fares JA, Oba IT, Cardoso MRA, Saraceni CP, Granato C. Prospective study of hepatitis C virus infection in hemodialysis patients by monthly analysis of HCV RNA and antibodies [Internet]. Canadian Journal of Microbiology. 2003 ; 49( 8): 503-507.[citado 2024 abr. 24 ] Available from: https://doi.org/10.1139/w03-065 - The role of respiratory viral infections among children hospitalized for community-acquired pneumonia in a developing country
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Informações sobre o DOI: 10.1139/w03-065 (Fonte: oaDOI API)
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