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Effects of creatine supplementation on renal function:: a randomized, double-blind, placebo-controlled clinical trial (2008)

  • Authors:
  • USP affiliated authors: JUNIOR, ANTONIO HERBERT LANCHA - EEFE ; UGRINOWITSCH, CARLOS - EEFE ; SHIMIZU, MARIA HELOISA MASSOLA - FM
  • USP Schools: EEFE; EEFE; FM
  • DOI: 10.1007/s00421-007-0669-3
  • Subjects: NUTRIÇÃO; SUPLEMENTAÇÃO ALIMENTAR; PLACEBOS; EXERCÍCIO FÍSICO
  • Language: Inglês
  • Abstract: Creatine (CR) supplementation is commonly used by athletes. However, its eVects on renal function remain controversial. The aim of this study was to evaluate the eVects of creatine supplementation on renal function in healthy sedentary males (18-35 years old) submitted to exercise training. A randomized, double-blind, placebo-controlled trial was performed. Subjects (n = 18) were randomly allocated to receive treatment with either creatine (CR) ("10 g day¡1 over 3 months) or placebo (PL) (dextrose). All subjects undertook moderate intensity aerobic training, in three 40-min sessions per week, during 3 months. Serum creatinine, serum and urinary sodium and potassium were determined at baseline and at the end of the study. Cystatin C was assessed prior to training (PRE), after 4 (POST 4) and 12 weeks (POST 12). Cystatin C levels (mg L¡1) (PRE CR: 0.82 § 0.09; PL: 0.88 § 0.07 vs. POST 12 CR: 0.71 § 0.06; PL: 0.75 § 0.09, P = 0.0001) were decreased over time, suggesting an increase in glomerular Wltration rate. Serum creatinine decreased with training in PL but was unchanged with training in CR. No signiWcant diVerences were observed within or between groups in other parameters investigated. The decrease in cystatin C indicates that highdose creatine supplementation over 3 months does not provoke any renal dysfunction in healthy males undergoing aerobic training. In addition, the results suggest that moderate aerobic training per se may improve renal function
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    Informações sobre o DOI: 10.1007/s00421-007-0669-3 (Fonte: oaDOI API)
    • Este periódico é de assinatura
    • Este artigo NÃO é de acesso aberto
    • Cor do Acesso Aberto: closed
    Informações sobre o Citescore
  • Título: European Journal of Applied Physiology

    ISSN: 1439-6319

    Citescore - 2017: 2.45

    SJR - 2017: 1.186

    SNIP - 2017: 1.215


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    EEFE10300022578-SPRO 2008 005
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    • ABNT

      GUALANO, Bruno; UGRINOWITSCH, Carlos; NOVAES, Rafael Batista; et al. Effects of creatine supplementation on renal function:: a randomized, double-blind, placebo-controlled clinical trial. European Journal of Applied Physiology, Berlin, v. 103, n. 1, p. 33-40, 2008. Disponível em: < http://www.springerlink.com.w10077.dotlib.com.br/content/m570621w6534k1l4/fulltext.pdf > DOI: 10.1007/s00421-007-0669-3.
    • APA

      Gualano, B., Ugrinowitsch, C., Novaes, R. B., Artioli, G. G., Shimizu, M. H., Seguro, A. C., et al. (2008). Effects of creatine supplementation on renal function:: a randomized, double-blind, placebo-controlled clinical trial. European Journal of Applied Physiology, 103( 1), 33-40. doi:10.1007/s00421-007-0669-3
    • NLM

      Gualano B, Ugrinowitsch C, Novaes RB, Artioli GG, Shimizu MH, Seguro AC, Harris RC, Lancha Junior AH. Effects of creatine supplementation on renal function:: a randomized, double-blind, placebo-controlled clinical trial [Internet]. European Journal of Applied Physiology. 2008 ; 103( 1): 33-40.Available from: http://www.springerlink.com.w10077.dotlib.com.br/content/m570621w6534k1l4/fulltext.pdf
    • Vancouver

      Gualano B, Ugrinowitsch C, Novaes RB, Artioli GG, Shimizu MH, Seguro AC, Harris RC, Lancha Junior AH. Effects of creatine supplementation on renal function:: a randomized, double-blind, placebo-controlled clinical trial [Internet]. European Journal of Applied Physiology. 2008 ; 103( 1): 33-40.Available from: http://www.springerlink.com.w10077.dotlib.com.br/content/m570621w6534k1l4/fulltext.pdf

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