Artigo de periodico

Effects of creatine supplementation on renal function:: a randomized, double-blind, placebo-controlled clinical trial (2008)

• Authors:
  • Gualano, Bruno
  • Ugrinowitsch, Carlos
  • Novaes, Rafael Batista
  • Artioli, G. G
  • Shimizu, Maria Heloisa - Universidade de São Paulo (USP)
  • Seguro, Antonio Carlos
  • Harris, Roger Charles
  • Lancha Junior, Antonio Herbert
• USP affiliated authors: SHIMIZU, MARIA HELOISA MASSOLA - FM ; JUNIOR, ANTONIO HERBERT LANCHA - EEFE ; UGRINOWITSCH, CARLOS - EEFE
• Unidades: FM; EEFE
• DOI: 10.1007/s00421-007-0669-3
• Subjects: NUTRIÇÃO; SUPLEMENTAÇÃO ALIMENTAR; PLACEBOS; EXERCÍCIO FÍSICO
• Language: Inglês
• Abstract: Creatine (CR) supplementation is commonly used by athletes. However, its eVects on renal function remain controversial. The aim of this study was to evaluate the eVects of creatine supplementation on renal function in healthy sedentary males (18-35 years old) submitted to exercise training. A randomized, double-blind, placebo-controlled trial was performed. Subjects (n = 18) were randomly allocated to receive treatment with either creatine (CR) ("10 g day¡1 over 3 months) or placebo (PL) (dextrose). All subjects undertook moderate intensity aerobic training, in three 40-min sessions per week, during 3 months. Serum creatinine, serum and urinary sodium and potassium were determined at baseline and at the end of the study. Cystatin C was assessed prior to training (PRE), after 4 (POST 4) and 12 weeks (POST 12). Cystatin C levels (mg L¡1) (PRE CR: 0.82 § 0.09; PL: 0.88 § 0.07 vs. POST 12 CR: 0.71 § 0.06; PL: 0.75 § 0.09, P = 0.0001) were decreased over time, suggesting an increase in glomerular Wltration rate. Serum creatinine decreased with training in PL but was unchanged with training in CR. No signiWcant diVerences were observed within or between groups in other parameters investigated. The decrease in cystatin C indicates that highdose creatine supplementation over 3 months does not provoke any renal dysfunction in healthy males undergoing aerobic training. In addition, the results suggest that moderate aerobic training per se may improve renal function
• Imprenta:
  • Publisher place: Berlin
  • Date published: 2008
• Source:
  • Título do periódico: European Journal of Applied Physiology
  • Volume/Número/Paginação/Ano: v. 103, n. 1, p. 33-40, maio 2008

Informações sobre o DOI: 10.1007/s00421-007-0669-3 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

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How to cite

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• ABNT

  GUALANO, Bruno et al. Effects of creatine supplementation on renal function:: a randomized, double-blind, placebo-controlled clinical trial. European Journal of Applied Physiology, v. 103, n. 1, p. 33-40, 2008Tradução . . Disponível em: https://doi.org/10.1007/s00421-007-0669-3. Acesso em: 19 abr. 2024.

• APA

  Gualano, B., Ugrinowitsch, C., Novaes, R. B., Artioli, G. G., Shimizu, M. H., Seguro, A. C., et al. (2008). Effects of creatine supplementation on renal function:: a randomized, double-blind, placebo-controlled clinical trial. European Journal of Applied Physiology, 103( 1), 33-40. doi:10.1007/s00421-007-0669-3

• NLM

  Gualano B, Ugrinowitsch C, Novaes RB, Artioli GG, Shimizu MH, Seguro AC, Harris RC, Lancha Junior AH. Effects of creatine supplementation on renal function:: a randomized, double-blind, placebo-controlled clinical trial [Internet]. European Journal of Applied Physiology. 2008 ; 103( 1): 33-40.[citado 2024 abr. 19 ] Available from: https://doi.org/10.1007/s00421-007-0669-3

• Vancouver

  Gualano B, Ugrinowitsch C, Novaes RB, Artioli GG, Shimizu MH, Seguro AC, Harris RC, Lancha Junior AH. Effects of creatine supplementation on renal function:: a randomized, double-blind, placebo-controlled clinical trial [Internet]. European Journal of Applied Physiology. 2008 ; 103( 1): 33-40.[citado 2024 abr. 19 ] Available from: https://doi.org/10.1007/s00421-007-0669-3

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