Quantification of propofol in smallvolumes of plasma using high-performance liquid chromatography with fluorescence detection: therapeutic drug monitoring of one patient (2007)
- Authors:
- USP affiliated authors: CARMONA, MARIA JOSE CARVALHO - FM ; AULER JUNIOR, JOSE OTAVIO COSTA - FM ; SANTOS, SILVIA REGINA CAVANI JORGE - FCF
- Unidades: FM; FCF
- Subjects: CROMATOGRAFIA LÍQUIDA; ELETROQUÍMICA
- Language: Inglês
- Abstract: A liquid chromatographic method with fluorescence detection for determination of propofol in small volumes of plasma has been adapted to the conditions of the laboratory using a C18 column. Peaks were eluted at 21 min propofol and at 12 min thymol (internal standard) using a binary mobile phase at flow rate 0.8 mL/min. The method validated presents 0.05 mg/L sensitivity, 0.1 - 10 mg/L linearity, ('r POT. 2' 0.9977), systematic error of 8.2 and 7.0% (intra- and interday accuracy), intra- and interday precision (CV %: 8.4% and 8.8%). Recovery 93.9%, good stability and robustness were reported. The analytical method was validated by the quantification of propofol in arterial plasma ('C IND. Max':3.3 mg/L 'CIND. Min': 0.2mg/L) of one patient received 1570 mg infusion of propofol in the perioperative period of surgery of myocardial revascularization. Depth of anaesthesia expressed as bispectral index (BIS) was 36 (32-40) in that period up to the '4 IND. Th', and an adequate hypnosis was obtained until the end of surgery
- Imprenta:
- Publisher place: Buenos Aires
- Date published: 2007
- Source:
- Título do periódico: Latin American Journal of Pharmacy = Acta Farmacéutica Bonaerense
- ISSN: 0326-2383
- Volume/Número/Paginação/Ano: v.26, n.5, p.748-754, 2007
-
ABNT
SILVA FILHO, Carlos Roberto da et al. Quantification of propofol in smallvolumes of plasma using high-performance liquid chromatography with fluorescence detection: therapeutic drug monitoring of one patient. Latin American Journal of Pharmacy = Acta Farmacéutica Bonaerense, v. 26, n. 5, p. 748-754, 2007Tradução . . Acesso em: 12 maio 2024. -
APA
Silva Filho, C. R. da, Kondo, R. T. O., Chignalia, A. Z., López, K. J. V., Pereira, V. A., Carmona, M. J. C., et al. (2007). Quantification of propofol in smallvolumes of plasma using high-performance liquid chromatography with fluorescence detection: therapeutic drug monitoring of one patient. Latin American Journal of Pharmacy = Acta Farmacéutica Bonaerense, 26( 5), 748-754. -
NLM
Silva Filho CR da, Kondo RTO, Chignalia AZ, López KJV, Pereira VA, Carmona MJC, Auler Júnior JOC, Santos SRCJ. Quantification of propofol in smallvolumes of plasma using high-performance liquid chromatography with fluorescence detection: therapeutic drug monitoring of one patient. Latin American Journal of Pharmacy = Acta Farmacéutica Bonaerense. 2007 ;26( 5): 748-754.[citado 2024 maio 12 ] -
Vancouver
Silva Filho CR da, Kondo RTO, Chignalia AZ, López KJV, Pereira VA, Carmona MJC, Auler Júnior JOC, Santos SRCJ. Quantification of propofol in smallvolumes of plasma using high-performance liquid chromatography with fluorescence detection: therapeutic drug monitoring of one patient. Latin American Journal of Pharmacy = Acta Farmacéutica Bonaerense. 2007 ;26( 5): 748-754.[citado 2024 maio 12 ] - Micrométodo para quantificação de cefuroxima em plasma através da cromatografia líquida de alta eficiência: Aplicação na profilaxia de pacientes submetidos à cirurgia cardíaca
- Case Report of propofol pharmacokinetic changes on target controlled infusion
- Modelagem farmacocinética do atenolol em pacientes com insuficiência coronariana grave submetidos à cirurgia cardíaca de revascularização com circulação extracorpórea
- Variabilidade das concentrações plasmáticas do atenolol na angina instável grave
- Quantificação de milrinona no plasma através de CLAE-UV-VIS aplicação no controle terapêutico de pacientes que necessitam de agentes inotrópicos vasodilatadores durante a cirurgia cardíaca
- Monitoramento terapêutico de propranolol em crianças com Tetralogia de Fallot
- Antibiotic prophyilaxiys in heart surgery with cefuroxime
- A micromethod for the quantification of atenolol in plasma using high-performance liquid chromatography with fluorescence detection - Therapeutic drug monitoring of two patients with severe coronary insufficiency before cardiac surgery
- Validação de metodologia analítica para quantificação de milrinona plasmática através de cromatografia líquida de alta eficiência (CLAE-UV)
- Therapeutic monitoring of propofol utilised for the induction and the maintenance of anaesthesia during coronary artery bypass grafting (CABG)
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
