Ver registro no DEDALUS
Exportar registro bibliográfico



Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell (2009)

  • Authors:
  • USP Schools: ICB; ICB; ICB
  • DOI: 10.1007/s00125-009-1536-z
  • Subjects: FISIOLOGIA
  • Language: Inglês
  • Imprenta:
  • Source:
    • Título do periódico: Diabetologia
    • ISSN: 1432-0428
    • Volume/Número/Paginação/Ano: v. 52, p. 2489-2498, 2009
  • Acesso online ao documento

    DOI or search this record in
    Informações sobre o DOI: 10.1007/s00125-009-1536-z (Fonte: oaDOI API)
    • Este periódico é de assinatura
    • Este artigo é de acesso aberto
    • URL de acesso aberto
    • Cor do Acesso Aberto: bronze
    Versões disponíveis em Acesso Aberto do: 10.1007/s00125-009-1536-z (Fonte: Unpaywall API)

    Título do periódico: Diabetologia

    ISSN: 0012-186X,1432-0428

    • Melhor URL em Acesso Aberto:

    • Outras alternativas de URLs em Acesso Aberto:
    Informações sobre o Citescore
  • Título: Diabetologia

    ISSN: 0012-186X

    Citescore - 2017: 5.09

    SJR - 2017: 3.228

    SNIP - 2017: 1.619

  • Exemplares físicos disponíveis nas Bibliotecas da USP
    BibliotecaCód. de barrasNúm. de chamada
    ICB12100026485PC-ICB BMB SEP 2009
    How to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas

    • ABNT

      NEWSHOLME, P.; MORGAN, D.; REBELATO, E.; et al. Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell. Diabetologia, Berlin, v. 52, p. 2489-2498, 2009. DOI: 10.1007/s00125-009-1536-z.
    • APA

      Newsholme, P., Morgan, D., Rebelato, E., Oliveira-Emilio, H. C., Araujo Filho, J. P. de, Curi, R., & Carpinelli, A. R. (2009). Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell. Diabetologia, 52, 2489-2498. doi:10.1007/s00125-009-1536-z
    • NLM

      Newsholme P, Morgan D, Rebelato E, Oliveira-Emilio HC, Araujo Filho JP de, Curi R, Carpinelli AR. Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell. Diabetologia. 2009 ; 52 2489-2498.
    • Vancouver

      Newsholme P, Morgan D, Rebelato E, Oliveira-Emilio HC, Araujo Filho JP de, Curi R, Carpinelli AR. Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell. Diabetologia. 2009 ; 52 2489-2498.

    Referências citadas na obra
    Newsholme P, Brennan L, Bender K (2006) Amino acid metabolism, β-cell function, and diabetes. Diabetes 55(Suppl 2):S39–S47
    Persaud SJ, Jones PM (1993) The involvement of protein kinase C in glucose stimulated insulin secretion. Biochem Soc Trans 21:428S
    Schrey MP, Montague W (1983) Phosphatidylinositol hydrolysis in isolated guinea-pig islets of Langerhans. Biochem J 216:433–441
    Newsholme P, Keane D, Welters HJ, Morgan NG (2007) Life and death decisions of the pancreatic β-cell: the role of fatty acids. Clin Sci (Lond) 112:27–42
    Metz SA (1988) Membrane phospholipid turnover as an intermediary step in insulin secretion. Putative roles of phospholipases in cell signaling. Am J Med 85:9–21
    Jones PM, Persaud SJ (1993) Arachidonic acid as a second messenger in glucose-induced insulin secretion from pancreatic beta-cells. J Endocrinol 137:7–14
    Keane D, Newsholme P (2008) Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic beta cells. Biochem Soc Trans 36:955–958
    Metz SA (1988) Exogenous arachidonic acid promotes insulin release from intact or permeabilized rat islets by dual mechanisms. Putative activation of Ca2+ mobilization and protein kinase C. Diabetes 37:1453–1469
    Kruman I, Guo Q, Mattson MP (1998) Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells. J Neurosci Res 51:293–308
    Yu JH, Kim KH, Kim H (2006) Role of NADPH oxidase and calcium in cerulein-induced apoptosis: involvement of apoptosis-inducing factor. Ann N Y Acad Sci 1090:292–297
    Morgan D, Oliveira-Emilio HR, Keane D et al (2007) Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line. Diabetologia 50:359–369
    Lortz S, Gurgul-Convey E, Lenzen S, Tiedge M (2005) Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines. Diabetologia 48:1541–1548
    Krause KH (2004) Tissue distribution and putative physiological function of NOX family NADPH oxidases. Jpn J Infect Dis 57:S28–S29
    Geiszt M (2006) NADPH oxidases: new kids on the block. Cardiovasc Res 71:289–299
    Borregaard N, Tauber AI (1984) Subcellular localization of the human neutrophil NADPH oxidase b-cytochrome and associated flavoprotein. J Biol Chem 259:47–52
    Vignais PV (2002) The superoxide-generating NADPH oxidase: structural aspects and activation mechanism. Cell Mol Life Sci 59:1428–1459
    Lambeth JD, Kawahara T, Diebold B (2007) Regulation of Nox and Duox enzymatic activity and expression. Free Radic Biol Med 43:319–331
    Bedard K, Krause KH (2007) The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87:245–313
    Koga H, Terasawa H, Nunoi H, Takeshige K, Inagaki F, Sumimoto H (1999) Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase. J Biol Chem 274:25051–25060
    Kawahara T, Quinn MT, Lambeth JD (2007) Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes. BMC Evol Biol 7:109
    Nisimoto Y, Motalebi S, Han CH, Lambeth JD (1999) The p67(phox) activation domain regulates electron flow from NADPH to flavin in flavocytochrome b(558). J Biol Chem 274:22999–23005
    Bedard K, Lardy B, Krause KH (2007) NOX family NADPH oxidases: not just in mammals. Biochimie 89:1107–1112
    Oliveira HR, Verlengia R, Carvalho CR, Britto LR, Curi R, Carpinelli AR (2003) Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase. Diabetes 52:1457–1463
    Banfi B, Molnar G, Maturana A et al (2001) A Ca(2+)-activated NADPH oxidase in testis, spleen, lymph nodes. J Biol Chem 276:37594–37601
    Sumimoto H (2008) Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. FEBS J 275:3249–3277
    Geiszt M, Leto TL (2004) The NOX family of NAD(P)H oxidases: host defense and beyond. J Biol Chem 279:51715–51718
    Takeya R, Ueno N, Kami K et al (2003) Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. J Biol Chem 278:25234–25246
    Uchizono Y, Takeya R, Iwase M et al (2006) Expression of isoforms of NADPH oxidase components in rat pancreatic islets. Life Sci 80:133–139
    Lapouge K, Smith SJ, Groemping Y, Rittinger K (2002) Architecture of the p40–p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phox. J Biol Chem 277:10121–10128
    Banfi B, Maturana A, Jaconi S et al (2000) A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science 287:138–142
    Sumimoto H, Miyano K, Takeya R (2005) Molecular composition and regulation of the Nox family NAD(P)H oxidases. Biochem Biophys Res Commun 338:677–686
    Cheng G, Diebold BA, Hughes Y, Lambeth JD (2006) Nox1-dependent reactive oxygen generation is regulated by Rac1. J Biol Chem 281:17718–17726
    Shiose A, Kuroda J, Tsuruya K et al (2001) A novel superoxide-producing NAD(P)H oxidase in kidney. J Biol Chem 276:1417–1423
    Kawahara T, Ritsick D, Cheng G, Lambeth JD (2005) Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation. J Biol Chem 280:31859–31869
    Martyn KD, Frederick LM, von Loehneysen K, Dinauer MC, Knaus UG (2006) Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal 18:69–82
    Brandes RP, Schröder K (2008) Composition and functions of vascular nicotinamide adenine dinucleotide phosphate oxidases. Trends Cardiovasc Med 18:15–19
    Guichard C, Moreau R, Pessayre D, Epperson TK, Krause KH (2008) NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes. Biochem Soc Trans 36:920–929
    Schröder K, Wandzioch K, Helmcke I, Brandes RP (2009) Nox4 acts as a switch between differentiation and proliferation in preadipocytes. Arterioscler Thromb Vasc Biol 29:239–245
    Mahadev K, Motoshima H, Wu X et al (2004) The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction. Mol Cell Biol 24:1844–1854
    Pi J, Bai Y, Zhang Q et al (2007) Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes 56:1783–1791
    Morgan D, Rebelato E, Abdulkader F et al (2009) Association of NAD(P)H oxidase with glucose-induced insulin secretion by pancreatic beta cells. Endocrinology 150:2197–2201
    Imoto H, Sasaki N, Iwase M et al (2008) Impaired insulin secretion by diphenyleneiodium associated with perturbation of cytosolic Ca2+ dynamics in pancreatic beta-cells. Endocrinology 149:5391–5400
    Zawalich WS, Zawalich KC (2008) Enhanced activation of phospholipase C and insulin secretion from islets incubated in fatty acid-free bovine serum albumin. Metabolism 57:290–298
    Oliveira HR, Curi R, Carpinelli AR (1999) Glucose induces an acute increase of superoxide dismutase activity in incubated rat pancreatic islets. Am J Physiol 276:C507–C510
    Leloup C, Tourrel-Cuzin C, Magnan C et al (2009) Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion. Diabetes 58:673–681
    Newsholme P, Haber EP, Hirabara SM et al (2007) Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. J Physiol 583:9–24
    Green K, Brand MD, Murphy MP (2004) Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes 53(Suppl 1):S110–S118
    Pi J, Bai Y, Daniel K et al (2009) Persistent oxidative stress due to absence of uncoupling protein 2 is associated with impaired pancreatic beta cell function. Endocrinology 150:3040–3048
    Halliwell B, Gutteridge JMC (2007) Free radicals in biology and medicine. Oxford University Press, Oxford
    Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T (1995) Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270:296–299
    Mahadev K, Zilbering A, Zhu L, Goldstein BJ (2001) Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade. J Biol Chem 276:21938–21942
    Peskin AV, Winterbourn CC (2006) Taurine chloramine is more selective than hypochlorous acid at targeting critical cysteines and inactivating creatine kinase and glyceraldehyde-3-phosphate dehydrogenase. Free Radic Biol Med 40:45–53
    Robertson RP, Zhang HJ, Pyzdrowski KL, Walseth TF (1992) Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations. J Clin Invest 90:320–325
    Kaneto H, Katakami N, Kawamori D et al (2007) Involvement of oxidative stress in the pathogenesis of diabetes. Antioxid Redox Signal 9:355–366
    Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S, Weir GC (2002) Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem 277:30010–30018
    Kaneto H, Kajimoto Y, Miyagawa J et al (1999) Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. Diabetes 48:2398–2406
    Lortz S, Tiedge M, Nachtwey T, Karlsen AE, Nerup J, Lenzen S (2000) Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes. Diabetes 49:1123–1130
    Malaisse WJ, Dufrane SP, Mathias PC et al (1985) The coupling of metabolic to secretory events in pancreatic islets. The possible role of glutathione reductase. Biochim Biophys Acta 844:256–264
    Ammon HP, Mark M (1985) Thiols and pancreatic beta-cell function: a review. Cell Biochem Funct 3:157–171
    Avshalumov MV, Chen BT, Koos T, Tepper JM, Rice ME (2005) Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels. J Neurosci 25:4222–4231
    Krippeit-Drews P, Kramer C, Welker S, Lang F, Ammon HP, Drews G (1999) Interference of H2O2 with stimulus-secretion coupling in mouse pancreatic beta-cells. J Physiol 514:471–481
    Maechler P, Jornot L, Wollheim CB (1999) Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. J Biol Chem 274:27905–27913
    Yan LJ, Levine RL, Sohal RS (1997) Oxidative damage during aging targets mitochondrial aconitase. Proc Natl Acad Sci U S A 94:11168–11172
    Brodie AE, Reed DJ (1987) Reversible oxidation of glyceraldehyde 3-phosphate dehydrogenase thiols in human lung carcinoma cells by hydrogen peroxide. Biochem Biophys Res Commun 148:120–125
    Du XL, Edelstein D, Rossetti L et al (2000) Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. Proc Natl Acad Sci U S A 97:12222–12226
    Molina y Vedia L, McDonald B, Reep B et al (1992) Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. J Biol Chem 267:24929–24932
    Bulteau AL, Ikeda-Saito M, Szweda LI (2003) Redox-dependent modulation of aconitase activity in intact mitochondria. Biochemistry 42:14846–14855
    Sakai K, Matsumoto K, Nishikawa T et al (2003) Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells. Biochem Biophys Res Commun 300:216–222
    Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414:813–820
    Martens GA, Cai Y, Hinke S, Stange G, van de Casteele M, Pipeleers D (2005) Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells. J Biol Chem 280:20389–20396
    Bell GI, Polonsky KS (2001) Diabetes mellitus and genetically programmed defects in β-cell function. Nature 414:788–791
    Kahn SE (2003) The relative contributions of insulin resistance and β-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3–19
    Cacicedo JM, Benjachareowong S, Chou E, Ruderman NB, Ido Y (2005) Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide. Diabetes 54:1838–1845
    Beeharry N, Chambers JA, Green IC (2004) Fatty acid protection from palmitic acid-induced apoptosis is lost following PI3-kinase inhibition. Apoptosis 9:599–607
    Pap M, Cooper GM (1998) Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem 273:19929–19932
    Cardone MH, Roy N, Stennicke HR et al (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science 282:1318–1321
    Datta SR, Dudek H, Tao X et al (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231–241
    Donath MY, Gross DJ, Cerasi E, Kaiser N (1999) Hyperglycemia-induced β-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes. Diabetes 48:738–744
    Efanova IB, Zaitsev SV, Zhivotovsky B et al (1998) Glucose and tolbutamide induce apoptosis in pancreatic β-cells. A process dependent on intracellular Ca2+ concentration. J Biol Chem 273:33501–33507
    Lenzen S (2008) Oxidative stress: the vulnerable beta-cell. Biochem Soc Trans 36:343–347
    Grover AK, Kwan CY, Samson CE (2003) Effects of peroxynitrite on sarco/endoplasmic reticulum Ca2+ pump isoforms SERCS2b and SERCA3a. Am J Physiol Cell Physiol 285:C1537–C1543
    Azevedo-Martins AK, Lortz S, Lenzen S, Curi R, Eizirik DL, Tiedge M (2003) Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells. Diabetes 52:93–101
    Sekiguchi F, Ishibashi K, Katoh H, Kawamoto Y, Ino T (1990) Genetic profile of alloxan-induced diabetes-susceptible mice (ALS) and resistant mice (ALR). Exp Anim 39:269–272
    Mathews CE, Leiter EH (1999) Constitutive differences in antioxidant defense status distinguishes alloxan resistant (ALR/Lt) and alloxan susceptible (ALS/Lt) mice. Free Radical Biol Med 27:449–455
    Mathews CE, Leiter EH (1999) Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait. Diabetes 48:2189–2196
    Mathews CE, Graser R, Savinov A, Serreze DV, Leiter EH (2001) The NOD/Lt-related ALR/Lt strain: unusual resistance of beta cells to autoimmune killing uncovers a role for beta-cell expressed resistance determinants. Proc Natl Acad Sci U S A 98:235–240
    Lenzen S (2008) The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 51:216–226
    Carro E, Torres-Aleman I (2004) The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer’s disease. Eur J Pharmacol 490:127–133
    Zhou J, Zhang S, Zhao X, Wei T (2008) Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid beta 1–42. J Pineal Res 45:157–165
    Mulder H, Nagorny CLF, Lyssenko V, Groop L (2009) Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene. Diabetologia 52:1240–1249