Ver registro no DEDALUS
Exportar registro bibliográfico



In situ screening of 3-arylcoumarin derivatives reveals new inhibitors of mast cell degranulation (2013)

  • Authors:
  • DOI: 10.1007/s12272-013-0084-8
  • Language: Inglês
  • Imprenta:
  • Source:
  • Acesso online ao documento

    Online accessDOI or search this record in
    Informações sobre o DOI: 10.1007/s12272-013-0084-8 (Fonte: oaDOI API)
    • Este periódico é de assinatura
    • Este artigo NÃO é de acesso aberto
    • Cor do Acesso Aberto: closed
    Informações sobre o Citescore
  • Título: Archives of Pharmacal Research

    ISSN: 0253-6269

    Citescore - 2017: 2.17

    SJR - 2017: 0.626

    SNIP - 2017: 0.736

  • Exemplares físicos disponíveis nas Bibliotecas da USP
    BibliotecaCód. de barrasNúm. de chamada
    FCFRP2406974pcd 2406974 Estantes Deslizantes
    How to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas

    • ABNT

      SANTOS, Marcela de Souza; DEL LAMA, Maria Perpetua Freire de Morais; DELIBERTO, Laila Aparecida; et al. In situ screening of 3-arylcoumarin derivatives reveals new inhibitors of mast cell degranulation. Archives of Pharmacal Research, Seoul, v. 36, n. 6, p. 731-738, 2013. Disponível em: < > DOI: 10.1007/s12272-013-0084-8.
    • APA

      Santos, M. de S., Del Lama, M. P. F. de M., Deliberto, L. A., Emery, F. da S., Pupo, M. T., & Naal, R. M. Z. G. (2013). In situ screening of 3-arylcoumarin derivatives reveals new inhibitors of mast cell degranulation. Archives of Pharmacal Research, 36( 6), 731-738. doi:10.1007/s12272-013-0084-8
    • NLM

      Santos M de S, Del Lama MPF de M, Deliberto LA, Emery F da S, Pupo MT, Naal RMZG. In situ screening of 3-arylcoumarin derivatives reveals new inhibitors of mast cell degranulation [Internet]. Archives of Pharmacal Research. 2013 ; 36( 6): 731-738.Available from:
    • Vancouver

      Santos M de S, Del Lama MPF de M, Deliberto LA, Emery F da S, Pupo MT, Naal RMZG. In situ screening of 3-arylcoumarin derivatives reveals new inhibitors of mast cell degranulation [Internet]. Archives of Pharmacal Research. 2013 ; 36( 6): 731-738.Available from:

    Referências citadas na obra
    Andrioli, W.J., M.S. Santos, V.B. Silva, R.B. Oliveira, A. Chagas-Paula, J.A. Jorge, N.A. Furtado, M.T. Pupo, C.H. Silva, R.M. Naal, and J.K. Bastos. 2012. δ-Lactam derivative from thermophilic soil fungus exhibits in vitro anti-allergic activity. Natural Product Research 26: 2168–2175.
    Barsumian, E.L., C. Isersky, M.G. Petrino, and R.P. Siraganian. 1981. IgE-induced histamine release from rat basophilic leukemia cell lines: isolation of releasing and nonreleasing clones. European Journal of Immunology 11: 317–323.
    Bissonnette, E.Y., G.M. Tremblay, V. Turmel, B. Pirotte, and M. Reboud-Rabaux. 2009. Coumarinic derivatives show anti-inflammatory effects on alveolar macrophages, but their anti-elastase activity is essential to reduce lung inflammation in vivo. International Immunopharmacology 9: 49–54.
    Cheong, H., S.Y. Ryu, M.H. Oak, S.H. Cheon, G.S. Yoo, and K.M. Kim. 1998. Studies of structure activity relationship of flavonoids for the anti-allergic actions. Archives of Pharmacal Research 4: 478–480.
    Choi, Y.H., and G.H. Yan. 2009. Anti-allergic effects of scoparone on mast cell-mediated allergy model. Phytomedicine 16: 1089–1094.
    Curtis, T., R.M.Z.G. Naal, C. Batt, J. Tabb, and D. Holowka. 2008. Development of a mast cell-based biosensor. Biosensors & Bioelectronics 23: 1024–1031.
    Hardy, R. 1986. Handbook of Experimental Immunology. Oxford: London.
    Hong, J., H. Sasaki, N. Hirasawa, K. Ishihara, J.H. Kwak, O. Zee, F.J. Schmitz, T. Seyama, and K. Ohuchi. 2009. Suppresion of the antigen-stimulated RBL-2H3 mast cell activation by Artekeiskeanol A. Planta Medica 14: 1494–1498.
    Hoult, J.R., and M. Payá. 1996. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. General Pharmacology 27: 713–722.
    Huber, R., F.C. Stintzing, D. Briemle, C. Beckmann, U. Meyer, and C. Gründemann. 2012. In vitro antiallergic effects of aqueous fermented preparations from Citrus and Cydonia fruits. Planta Medica 78: 334–340.
    Kabeya, L.M., C.H. da Silva, A. Kanashiro, J.M. Campos, A.E. Azzolini, A.C. Polizello, M.T. Pupo, and Y.M. Lucisano-Valim. 2008. Inhibition of immune complex-mediated neutrophil oxidative metabolism: a pharmacophore model for 3-phenylcoumarin derivatives using GRIND-based 3D-QSAR and 2D-QSAR procedures. European Journal of Medicinal Chemistry 43: 996–1007.
    Kabeya, L.M., A.A. de Marchi, A. Kanashiro, N.P. Lopes, C.H. da Silva, M.T. Pupo, and Y.M. Lucisano-Valim. 2007. Inhibition of horseradish peroxidase catalytic activity by new 3-phenylcoumarin derivatives: synthesis and structure-activity relationships. Bioorganic & Medicinal Chemistry 15: 1516–1524.
    Kambayashi, T., and G.A. Koretzky. 2007. Proximal signaling events in Fc epsilon RI-mediated mast cell activation. The Journal of Allergy and Clinical Immunology 119: 544–552.
    Kang, K.H., C.S. Kong, Y. Seo, M.M. Kim, and S.K. Kim. 2009. Anti-inflammatory effect of coumarins isolated from Corydalis heterocarpa in HT-29 human colon carcinoma cells. Food and Chemical Toxicology 47: 2129–2134.
    Kim, J.W., J.H. Lee, B.Y. Hwang, S.H. Mun, N.Y. Ko, K. Kim, B. Kim, H.S. Kim, Y.M. Kim, and W.S. Choi. 2009. Morin inhibits Fyn kinase in mast cell and IgE-mediated type I hypersensitivity response in vivo. Biochemical Pharmacology 77: 1506–1512.
    Kontogiorgis, C., and D. Hadjipavlou-Litina. 2003. Biological evaluation of several coumarin derivatives designed as possible anti-inflammatory/antioxidant agents. Journal of Enzyme Inhibition and Medicinal Chemistry 18: 63–69.
    Kostova, I., Raleva, S., Genova, P., Argirova, R., (2006). Structure-activity relationships of synthetic coumarins as HIV inhibitors. Bioinorganic Chemistry and Applications 2006: Article ID 68274.
    Joo, S.S., D. Park, S. Shin, J.H. Jeon, T.K. Kim, Y.J. Choi, S.H. Lee, J.S. Kim, S.K. Park, B.Y. Hwang, B.Y. Lee, and Y.B. Kim. 2010. Anti-allergic effects and mechanisms of action of the ethanolic extract of Angelica gigas in dinitrofluorobenzene-induced inflammation models. Environmental Toxicology and Pharmacology 30: 127–133.
    Lambiase, A., A. Micera, and S. Bonini. 2009. Multiple action agents and the eye: do they really stabilize mast cells? Current opinion in Allergy and Clinical Immunology 9: 454–465.
    de Marchi, A.A., M.S. Castilho, P.G. Nascimento, F.C. Archanjo, G. del Ponte, G. Oliva, and M.T. Pupo. 2004. New 3-piperonylcoumarins as inhibitors of glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) from Trypanosoma cruzi. Bioorganic & Medicinal Chemistry 12: 4823–4833.
    Masuda, E.S., and J. Schmitz. 2008. Syk inhibitors as treatment for allergic rhinitis. Pulmonary Pharmacology & Therapeutics 21: 461–467.
    Matsuda, H., T. Morikawa, H. Managi, and M. Yoshikawa. 2003. Antiallergic principles from Alpinia galanga: structural requirements of phenylpropanoids forinhibition of degranulation and release of TNF-alpha and IL-4 in RBL-2H3 cells. Bioorganic & Medicinal Chemistry Letters 13: 3197–3202.
    Mastuda, H., T. Morikawa, K. Ueda, H. Managi, and M. Yoshikawa. 2002. Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells. Bioorganic & Medicinal Chemistry 10: 3123–3128.
    Melagraki, G., A. Afantitis, O. Igglessi-Markopoulou, A. Detsi, M. Koufaki, C. Kontogiorgis, and D.J. Hadjipavlou-Litina. 2009. Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts. European Journal of Medicinal Chemistry 44: 3020–3026.
    Metzger, H. 1992. The receptor with high affinity for IgE. Immunological Reviews 125: 37–48.
    Mishra, R., K.K. Jha, S. Kumar, and I. Tomer. 2011. Synthesis, properties and biological activity of thiophene: a review. Der Pharma Chemica 3: 38–54.
    Moon, P.D., B.H. Lee, H.J. Jeong, H.J. An, S.J. Park, H.R. Kim, S.G. Ko, J.Y. Um, S.H. Hong, and H.M. Kim. 2007. Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition the IkappaB/NF-kappaB signal cascade in the human mast cell line HMC-1. European Journal of Pharmacology 555: 218–225.
    Moriya, K., J. Rivera, S. Odom, Y. Sakuma, K. Muramato, T. Yoshiuchi, M. Miyamoto, and K. Yamada. 1997. ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fcε receptor I-mediated activation of Syk. Proceedings of the National Academy of Sciences of the United States of America 94: 12539–12544.
    Naal, R.M.Z.G., J. Tabb, D. Holowka, and B. Baird. 2004. In situ measurement of degranulation as a biosensor based on RBL-2H3 mast cells. Biosensors & Bioelectronics 20: 791–796.
    Nakano, N., C. Nishiyama, T. Tokura, Y. Nagasako-Akazome, Y. Ohtake, K. Okumura, and H. Ogawa. 2008. Procyanidin C1 from apple extracts inhibits Fc epsilon RI-mediated mast cell activation. International Archives of Allergy and Immunology 147: 213–221.
    Pedersen, J.Z., C. Oliveira, S. Incerpi, V. Kumar, A.M. Fiore, P. De Vito, A.K. Prasad, S.V. Malhotra, V.S. Parmar, and L. Saso. 2007. Antioxidant activity of 4-methylcoumarins. Journal of Pharmacy and Pharmacology 59: 1721–1728.
    Posner, R.G., B. Lee, D.H. Conrad, D. Holowka, B. Baird, and B. Goldstein. 1992. Aggregation of IgE-receptor complexes on rat basophilic leukemia cells does not change the intrinsic affinity but can alter the kinetics of the ligand-IgE interaction. Biochemistry 31: 5350–5356.
    Riveiro, M.E., N. De Kimpe, A. Moglioni, R. Vázquez, F. Monczor, C. Shayo, and C. Davio. 2010. Coumarins: old compounds with novel promising therapeutic perspectives. Current Medicinal Chemistry 17: 1325–1338.
    Rossi, A.B., E. Herlaar, S. Braselmann, S. Huynh, V. Taylor, R. Frances, S.D. Issakani, A. Argade, R. Singh, D.G. Payan, and E. Masuda. 2006. Identification of the Syk kinase inhibitor R112 by a human mast cell screen. Journal of Allergy and Clinical Immunology 118: 749–755.
    Ryu, S.Y., N.Y. Kou, H.S. Choi, H. Ryu, T.S. Kim, and K.M. Kim. 2001. Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells. Planta Medica 67: 172–174.
    Serna, H., M. Porras, and P. Vergara. 2006. Mast cell stabilizer ketotifen [4-(1-methyl-4-piperidylidene)-4 h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate] prevents mucosal mast cell hyperplasia and intestinal dysmotility in experimental Trichinella spiralis inflammation in the rat. Journal of Pharmacology and Experimental Therapeutics 319: 1104–1111.
    Smyth, T., V.N. Ramachandran, and W.F. Smyth. 2009. A study of the antimicrobial activity of selected naturally occurring and synthetic coumarins. International Journal of Antimicrobial Agents 33: 421–426.
    Tanifuji, S., E. Aizu-Yokota, M. Funakoshi-Tago, Y. Sonoda, H. Inoue, and T. Kasahara. 2010. Licochalcones suppress degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells. International Immunopharmacology 10: 769–776.
    Waffo, A.K., G.A. Azebaze, A.E. Nkengfack, Z.T. Fomum, M. Meyer, B. Bodo, and F.R. van Heerden. 2000. Indicanines B and C, two isoflavonoid derivatives from the root bark of Erythrina indica. Phytochemistry 53: 981–985.
    Wang, Q., H. Matsuda, K. Matsuhira, S. Nakamura, D. Yuan, and M. Yoshikawa. 2007. Inhibitory effects of thunberginols A, B, and F on degranulations and releases of TNF-alpha and IL-4 in RBL-2H3 cells. Biological & Pharmaceutical Bulletin 30: 388–392.
    Wu, L., X. Wang, W. Xu, F. Farzaneh, and R. Xu. 2009. The structure and pharmacological functions of coumarins and their derivatives. Current Medicinal Chemistry 16: 4236–4260.