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Influence of aeration-homogenization system in stirred tank bioreactors, dissolved oxygen concentration and pH control mode on BHK-21 cell growth and metabolism (2013)

  • Authors:
  • USP affiliated authors: TONSO, ALDO - EP
  • USP Schools: EP
  • DOI: 10.1007/s10616-013-9612-0
  • Subjects: CÉLULAS (CRESCIMENTO E DESENVOLVIMENTO); REATORES BIOQUÍMICOS
  • Language: Inglês
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    Informações sobre o DOI: 10.1007/s10616-013-9612-0 (Fonte: oaDOI API)
    • Este periódico é de assinatura
    • Este artigo é de acesso aberto
    • URL de acesso aberto
    • Cor do Acesso Aberto: green
    Informações sobre o Citescore
  • Título: Cytotechnology

    ISSN: 0920-9069

    Citescore - 2017: 1.46

    SJR - 2017: 0.519

    SNIP - 2017: 0.601


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    • ABNT

      NÚÑES, Eutimio Gustavo Fernández; LEME, Jaci; PARIZOTTO, Letícia de Almeida; et al. Influence of aeration-homogenization system in stirred tank bioreactors, dissolved oxygen concentration and pH control mode on BHK-21 cell growth and metabolism. Cytotechnology, Netherlands, Springer, 2013. DOI: 10.1007/s10616-013-9612-0.
    • APA

      Núñes, E. G. F., Leme, J., Parizotto, L. de A., Chagas, W. A., Rezende, A. G. de, Costa, B. L. V., et al. (2013). Influence of aeration-homogenization system in stirred tank bioreactors, dissolved oxygen concentration and pH control mode on BHK-21 cell growth and metabolism. Cytotechnology. doi:10.1007/s10616-013-9612-0
    • NLM

      Núñes EGF, Leme J, Parizotto L de A, Chagas WA, Rezende AG de, Costa BLV, Monteiro DCV, Boldorini VLL, Jorge SAC, Astray, Pereira CA, Caricati CP, Tonso A. Influence of aeration-homogenization system in stirred tank bioreactors, dissolved oxygen concentration and pH control mode on BHK-21 cell growth and metabolism. Cytotechnology. 2013 ;
    • Vancouver

      Núñes EGF, Leme J, Parizotto L de A, Chagas WA, Rezende AG de, Costa BLV, Monteiro DCV, Boldorini VLL, Jorge SAC, Astray, Pereira CA, Caricati CP, Tonso A. Influence of aeration-homogenization system in stirred tank bioreactors, dissolved oxygen concentration and pH control mode on BHK-21 cell growth and metabolism. Cytotechnology. 2013 ;

    Referências citadas na obra
    Astley K, Naciri M, Racher A, Al-Rubeai M (2007) The role of p21cip1 in adaptation of CHO cells to suspension and protein-free culture. J Biotechnol 130:282–290
    Augusto EFP, Moraes AM, Piccoli RAM, Barral MF, Suazo CAT, Tonso A, Pereira CA (2010) Nomenclature and guideline to express the amount of a membrane protein synthesized in animal cells in view of bioprocess optimization and production monitoring. Biologicals 38:105–112
    Auniņš JG (2010) Viral vaccine production in cell culture. In: Flickinger MC (ed) Encyclopedia of industrial biotechnology: bioprocess, bioseparation, and cell technology. Wiley, New York, pp 1–35
    Birch JR (2010) Suspension culture, animal cells. In: Flickinger MC (ed) Encyclopedia of industrial biotechnology: bioprocess, bioseparation, and cell technology. Wiley, Hoboken, pp 1–28
    Bödeker BGD, Newcomb R, Yuan P, Braufman A, Kelsey W (1994) Production of recombinant factor VIII from perfusion cultures: I. Large-scale fermentation. In: Spier RE, Griffiths JB, Berthold W (eds) Animal cell technology: Products of today, prospects for tomorrow. Butterworth-Heinemann, Oxford, UK, pp. 580–583
    Butler M (2005) Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals. Appl Microbiol Biotechnol 68:283–291
    Butler M, Jenkins H (1989) Nutritional aspects of the growth of animal cells in culture. J Biotechnol 12:97–110
    Cruz HJ, Ferreira AS, Freitas CM, Moreira JL, Carrondo MJT (1999) Metabolic responses to different glucose and glutamine levels in baby hamster kidney cell culture. Appl Microbiol Biotechnol 51:579–585
    Cruz HJ, Freitas CM, Alves PM, Moreira JL, Carrondo MJT (2000a) Effects of ammonia and lactate on growth, metabolism, and productivity of BHK cells. Enzyme Microb Tech 27:43–52
    Cruz HJ, Moreira JL, Carrondo MJT (2000b) Metabolically optimised BHK cell fed-batch cultures. J Biotechnol 80:109–118
    Cruz HJ, Conradt HS, Dunker R, Peixoto CM, Cunha AE, Thomaz M, Burger C, Dias EM, Clemente J, Moreira JL, Rieke E, Carrondo MJT (2002) Process development of a recombinant antibody/interleukin-2 fusion protein expressed in protein-free medium by BHK cells. J Biotechnol 96:169–183
    Dietmair S, Nielsen LK, Timmins NE (2012) Mammalian cells as biopharmaceutical production hosts in the age of omics. Biotechnol J 7:75–89
    Doelle HW, Fiechter A, van Griensven M, Kasper C, Pörtner R, Schlegel G, Shimizu S, Stahl F, Suck K, Yamada H, Zorn H (2009) Biotechnology 6. Special applications. Ullmann’s encyclopedia of industrial chemistry. Wiley, New York, pp 73–112
    Garcia-Ochoa F, Gomez E, Santos VE, Merchuk JC (2010) Oxygen uptake rate in microbial processes: an overview. Biochem Eng J 49:289–307
    Handa-Corrigan A, Emery AN, Spier RE (1989) Effect of gas–liquid interfaces on the growth of suspended mammalian cells: mechanisms of cell damage by bubbles. Enzyme Microb Tech 11:230–235
    Ishaque A, Thrift J, Murphy JE, Konstantinov K (2007) Over-expression of Hsp70 in BHK-21 cells engineered to produce recombinant factor VIII promotes resistance to apoptosis and enhances secretion. Biotechnol Bioeng 97:144–155
    Jorjani P, Ozturk SS (1999) Effects of cell density and temperature on oxygen consumption rate for different mammalian cell lines. Biotechnol Bioen 64:349–356
    Kallel H, Rourou S, Majoul S, Loukil H (2003) A novel process for the production of a veterinary rabies vaccine in BHK-21 cells grown on microcarriers in a 20-l bioreactor. App Microbiol Biotechnol 61:441–446
    Kelley BD, Chiou TW, Rosenberg M, Wang DIC (2008) Industrial animal cell culture. In: Rehm HJ, Reed G (eds) Biotechnology set, 2nd edn. Wiley, Weinheim, pp 23–38
    Krampe B, Al-Rubeai M (2010) Cell death in mammalian cell culture: molecular mechanisms and cell line engineering strategies. Cytotechnology 62:175–188
    Li F, Vijayasankaran N, Shen AY, Kiss R, Amanullah A (2010) Cell culture processes for monoclonal antibody production. MAbs 2:466–477
    Merten O-W (2004) State-of-the-art of the production of retroviral vectors. J Gene Med 6:S105–S124
    Merten O-W (2006) Introduction to animal cell culture technology—past, present and future. Cytotechnology 50:1–7
    Mirro R, Voll K (2009) Which impeller is right for your cell line? A guide to impeller selection for stirred-tank bioreactors. BioProcess Int 7:52–57
    Molina-Grima E, Chisti Y, Moo-Young M (1997) Characterization of shear rates in airlift bioreactors for animal cell culture. J Biotechnol 54:195–210
    Moreira JL, Alves PM, Feliciano AS, Aunins JG, Carrondo MJT (1995) Serum-free and serum-containing media for growth of suspended BHK aggregates in stirred vessels. Enzyme Microb Tech 17:437–444
    Mulukutla BC, Khan S, Lange A, Hu WS (2010) Glucose metabolism in mammalian cell culture: new insights for tweaking vintage pathways. Trends Biotechnol 28:476–484
    Ozturk SS, Palsson BO (1990) Chemical decomposition of glutamine in cell culture media: effect of media type, pH, and serum concentration. Biotechnol Prog 6:121–128
    Park JH, Park HH, Park TH (2010) Cellular engineering for the high-level production of recombinant proteins in mammalian cell systems. Korean J Chem Eng 27:1042–1048
    Perrin P, Madhusudana S, Gontier-Jallet C, Petres S, Tordo N, Merten O-W (1995) An experimental rabies vaccine produced with a new BHK-21 suspension cell culture process: use of serum-free medium and perfusion-reactor system. Vaccine 13:1244–1250
    Radlett PJ, Telling RC, Stone J, Whiteside JP (1971) Improvements in the growth of BHK-21 cells in submerged culture. Appl Microbiol 22:534–537
    Sambanis A, Hu WS (2008) Cell culture bioreactors. In: Rehm HJ, Reed G (eds) Biotechnology set, 2nd edn. Wiley, Weinheim, pp 105–125
    Scargiali F, Busciglio A, Grisafi F, Brucato A (2010) Simplified dynamic pressure method for kLa measurement in aerated bioreactors. Biochem Eng J 49:165–172
    Schneider M, Marison IW, von Stockar U (1996) The importance of ammonia in mammalian cell culture. J Biotechnol 46:161–185
    Seewöster T, Lehmann J (1997) Cell size distribution as a parameter for the predetermination of exponential growth during repeated batch cultivation of CHO cells. Biotechnol Bioeng 55:793–797
    Silva AC, Delgado I, Sousa MFQ, Carrondo MJT, Alves PM (2008) Scalable culture systems using different cell lines for the production of Peste des Petits ruminants vaccine. Vaccine 26:3305–3311
    Teixeira A, Cunha AE, Clemente JJ, Moreira JL, Cruz HJ, Alves PM, Carrondo MJT, Oliveira R (2005) Modelling and optimization of a recombinant BHK-21 cultivation process using hybrid grey-box systems. J Biotechnol 118:290–303
    Vester D, Rapp E, Kluge S, Genzel Y, Reichl U (2010) Virus–host cell interactions in vaccine production cell lines infected with different human influenza A virus variants: a proteomic approach. J Proteomics 73:1656–1669