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Exploratory studies of the potential anti-cancer effects of creatine (2016)

  • Authors:
  • USP Schools: EEFE; IB; ICB; EEFE
  • DOI: 10.1007/s00726-016-2180-9
  • Language: Inglês
  • Imprenta:
    • Publisher place: Wien
    • Date published: 2016
  • Source:
    • Título do periódico: Amino Acids
    • ISSN: 0939-4451
    • Volume/Número/Paginação/Ano: v. 48, n. 8, p. 1993-2001, ago. 2016
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    Informações sobre o DOI: 10.1007/s00726-016-2180-9 (Fonte: oaDOI API)
    • Este periódico é de assinatura
    • Este artigo NÃO é de acesso aberto
    Versões disponíveis em Acesso Aberto do: 10.1007/s00726-016-2180-9 (Fonte: Unpaywall API)

    Título do periódico: Amino Acids

    ISSN: 0939-4451,1438-2199

      Não possui versão em Acesso aberto
    Informações sobre o Citescore
  • Título: Amino Acids

    ISSN: 0939-4451

    Citescore - 2017: 2.94

    SJR - 2017: 1.135

    SNIP - 2017: 0.989

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    • ABNT

      CAMPOS-FERRAZ, P. L; GUALANO, Bruno; NEVES, Walter Alves; et al. Exploratory studies of the potential anti-cancer effects of creatine. Amino Acids, Wien, v. 48, n. 8, p. 1993-2001, 2016. Disponível em: < > DOI: 10.1007/s00726-016-2180-9.
    • APA

      Campos-Ferraz, P. L., Gualano, B., Neves, W. A., Andrade, I. T., Hangai, I., Pereira, R. T. S., et al. (2016). Exploratory studies of the potential anti-cancer effects of creatine. Amino Acids, 48( 8), 1993-2001. doi:10.1007/s00726-016-2180-9
    • NLM

      Campos-Ferraz PL, Gualano B, Neves WA, Andrade IT, Hangai I, Pereira RTS, Bezerra RN, Deminice R, Seelaender MCL, Lancha Junior AH. Exploratory studies of the potential anti-cancer effects of creatine [Internet]. Amino Acids. 2016 ; 48( 8): 1993-2001.Available from:
    • Vancouver

      Campos-Ferraz PL, Gualano B, Neves WA, Andrade IT, Hangai I, Pereira RTS, Bezerra RN, Deminice R, Seelaender MCL, Lancha Junior AH. Exploratory studies of the potential anti-cancer effects of creatine [Internet]. Amino Acids. 2016 ; 48( 8): 1993-2001.Available from:

    Referências citadas na obra
    Alves C et al (2012) No effect of creatine supplementation on oxidative stress and cardiovascular parameters in spontaneously hypertensive rats. J Int Soc Sports Nutr 9:1–4. doi: 10.1186/1550-2783-9-13
    Avila-Díaz M et al (2006) Inflammation and extracellular volume expansion are related to sodium and water removal in patients on peritoneal dialysis. Perit Dial Int 26:574–580
    Barros M et al (2012) Effects of acute creatine supplementation on iron homeostasis and uric acid-based antioxidant capacity of plasma after wingate test. J Int Soc Sports Nutr 9:25–34. doi: 10.1186/1550-2783-9-25
    Bassit RA, Curi R, Costa Rosa LF (2008) Creatine supplementation reduces plasma levels of pro-inflammatory cytokines and PGE2 after a half-ironman competition. Amino Acids 35:425–431. doi: 10.1007/s00726-007-0582-4
    Bera S, Wallimann T, Ray S, Ray M (2008) Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells. FEBS J 275:5899–5909. doi: 10.1111/j.1742-4658.2008.06718.x
    Bergnes G, Yuan W, Khandekar V, OKeefe M, Martin K, Teicher B, KaddurahDaouk R (1996) Creatine and phosphocreatine analogs: anticancer activity and enzymatic analysis. Oncol Res 8:121–130
    Bodin P, Burnstock G (1998) Increased release of ATP from endothelial cells during acute inflammation. Inflamm Res 47:351–354
    Breit S et al (2011) The TGF-beta superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism. Growth Factors 29:187–195. doi: 10.3109/08977194.2011.607137
    Carr BM, Webster MJ, Boyd JC, Hudson GM, Scheett TP (2013) Sodium bicarbonate supplementation improves hypertrophy-type resistance exercise performance. Eur J Appl Physiol 113:743–752. doi: 10.1007/s00421-012-2484-8
    Chiche J, Brahimi-Horn MC, Pouysségur J (2010) Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J Cell Mol Med 14:771–794. doi: 10.1111/j.1582-4934.2009.00994.x
    Chiche J, Ricci JE, Pouysségur J (2013) Tumor hypoxia and metabolism—towards novel anticancer approaches. Ann Endocrinol (Paris) 74:111–114. doi: 10.1016/j.ando.2013.02.004
    Cooper R, Naclerio F, Allgrove J, Jimenez A (2012) Creatine supplementation with specific view to exercise/sports performance: an update. J Int Soc Sports Nutr 9:33. doi: 10.1186/1550-2783-9-33
    DeLuca M, Hall N, Rice R, Kaplan NO (1981) Creatine kinase isozymes in human tumors. Biochem Biophys Res Commun 99:189–195
    Deminice R, Jordao A (2012) Creatine supplementation reduces oxidative stress biomarkers after acute exercise in rats. Amino Acids 43:709–715. doi: 10.1007/s00726-011-1121-x
    Deminice R, Rosa FT, Franco GS, Jordao AA, de Freitas EC (2013) Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans. Nutrition 29:1127–1132. doi: 10.1016/j.nut.2013.03.003
    Goldszmid RS, Dzutsev A, Trinchieri G (2014) Host immune response to infection and cancer: unexpected commonalities. Cell Host Microbe 15:295–305. doi: 10.1016/j.chom.2014.02.003
    Gualano B et al (2008) Effects of creatine supplementation on glucose tolerance and insulin sensitivity in sedentary healthy males undergoing aerobic training. Amino Acids 34:245–250. doi: 10.1007/s00726-007-0508-1
    Gualano B, Roschel H, Lancha A, Brightbill C, Rawson E (2012) In sickness and in health: the widespread application of creatine supplementation. Amino Acids 43:519–529. doi: 10.1007/s00726-011-1132-7
    Guimaraes-Ferreira L, Pinheiro C, Gerlinger-Romero F, Vitzel K, Nachbar R, Curi R, Nunes M (2012) Short-term creatine supplementation decreases reactive oxygen species content with no changes in expression and activity of antioxidant enzymes in skeletal muscle. Eur J Appl Physiol 112:3905–3911. doi: 10.1007/s00421-012-2378-9
    Koetting J, Henninger C, Drevs A, MaierLenz H, Sonntag O (1996) Activity of creatine-kinase (CK) and subunit CK-MB in patients with different high malignant tumor diseases. Clin Chem 42:674
    Kornacker M et al (2001) Hodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis. Int J Cancer 94:513–519
    Kristensen CA, Askenasy N, Jain RK, Koretsky AP (1999) Creatine and cyclocreatine treatment of human colon adenocarcinoma xenografts: 31P and 1H magnetic resonance spectroscopic studies. Br J Cancer 79:278–285. doi: 10.1038/sj.bjc.6690045
    Lillie JW, O’Keefe M, Valinski H, Hamlin HA, Varban ML, Kaddurah-Daouk R (1993) Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits growth of a broad spectrum of cancer cells derived from solid tumors. Cancer Res 53:3172–3178
    Locasale JW (2013) Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer 13:572–583. doi: 10.1038/nrc3557
    Machado AP, Costa Rosa LF, Seelaender MC (2004) Adipose tissue in Walker 256 tumour-induced cachexia: possible association between decreased leptin concentration and mononuclear cell infiltration. Cell Tissue Res 318:503–514. doi: 10.1007/s00441-004-0987-2
    Martin K, Chen S, Clark G, Degen D, Wajima M, Vonhoff D, Kaddurahdaouk R (1994) Evaluation of creatine analogs as a new class of anticancer agents using freshly explanted human tumor-cells. J Natl Cancer Inst 86:608–613. doi: 10.1093/jnci/86.8.608
    Miller E, Evans A, Cohn M (1993) Inhibition of rate of tumor-growth by creatine and cyclocreatine. Proc Natl Acad Sci USA 90:3304–3308
    Muller L, Gnoyke S, Popken A, Bohm V (2010) Antioxidant capacity and related parameters of different fruit formulations. LWT Food Sci Technol 43:7
    Nicastro H et al (2012) Effects of creatine supplementation on muscle wasting and glucose homeostasis in rats treated with dexamethasone. Amino Acids 42:1695–1701. doi: 10.1007/s00726-011-0871-9
    Niu KY, Ro JY (2011) Changes in intramuscular cytokine levels during masseter inflammation in male and female rats. Neurosci Lett 487:223–227. doi: 10.1016/j.neulet.2010.10.027
    Nuzzo R (2014) Scientific method: statistical errors. Nature 506:150–152. doi: 10.1038/506150a
    Nuzzo RL (2015) The inverse fallacy and interpreting P values. PMR J 7:311–314. doi: 10.1016/j.pmrj.2015.02.011
    Ohira Y, Inoue N (1995) Effects of creatine and beta-guanidinopropionic acid on the growth of Erlich ascites tumor-cells—IP injection and culture study. Biochim Biophys Acta Gen Subj 1243:367–372. doi: 10.1016/0304-4165(94)00161-P
    Onda T, Uzawa K, Endo Y, Bukawa H, Yokoe H, Shibahara T, Tanzawa H (2006) Ubiquitous mitochondrial creatine kinase downregulated in oral squamous cell carcinoma. Br J Cancer 94:698–709. doi: 10.1038/sj.bjc.6602986
    Patra S et al (2008) Progressive decrease of phosphocreatine, creatine and creatine kinase in skeletal muscle upon transformation to sarcoma. FEBS J 275:3236–3247. doi: 10.1111/j.1742-4658.2008.06475.x
    Patra S et al (2012) A short review on creatine-creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy. Amino Acids 42:2319–2330. doi: 10.1007/s00726-011-0974-3
    Pereira RT, Porto CS, Abdalla FM (2014) Ovariectomy and 17β-estradiol replacement play a role on the expression of endonuclease-G and phosphorylated cyclic AMP response element-binding (CREB) protein in hippocampus. Mol Cell Endocrinol 382:227–233. doi: 10.1016/j.mce.2013.09.037
    Santos RV, Bassit RA, Caperuto EC, Costa Rosa LF (2004) The effect of creatine supplementation upon inflammatory and muscle soreness markers after a 30 km race. Life Sci 75:1917–1924. doi: 10.1016/j.lfs.2003.11.036
    Sestili P et al (2006) Creatine supplementation affords cytoprotection in oxidatively injured cultured mammalian cells via direct antioxidant activity. Free Radic Biol Med 40:837–849. doi: 10.1016/j.freeradbiomed.2005.10.035
    Shatton JB, Morris HP, Weinhouse S (1979) Creatine kinase activity and isozyme composition in normal tissues and neoplasms of rats and mice. Cancer Res 39:492–501
    Smith AE, Fukuda DH, Ryan ED, Kendall KL, Cramer JT, Stout J (2011) Ergolytic/ergogenic effects of creatine on aerobic power. Int J Sports Med 32:975–981. doi: 10.1055/s-0031-1283179
    Tang FC, Chan CC, Kuo PL (2013) Contribution of creatine to protein homeostasis in athletes after endurance and sprint running. Eur J Nutr. doi: 10.1007/s00394-013-0498-6
    Tarnopolsky MA, Bourgeois JM, Snow R, Keys S, Roy BD, Kwiecien JM, Turnbull J (2003) Histological assessment of intermediate- and long-term creatine monohydrate supplementation in mice and rats. Am J Physiol Regul Integr Comp Physiol 285:R762–R769. doi: 10.1152/ajpregu.00270.2003
    Tayek JA, Istfan NW, Jones CT, Hamawy KJ, Bistrian BR, Blackburn GL (1986) Influence of the Walker 256 carcinosarcoma on muscle, tumor, and whole-body protein synthesis and growth rate in the cancer-bearing rat. Cancer Res 46:5649–5654
    Tokarska-Schlattner M et al (2012) Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effects. PLoS One 7:e43178. doi: 10.1371/journal.pone.0043178
    Wallimann T, Tokarska-Schlattner M, Schlattner U (2011) The creatine kinase system and pleiotropic effects of creatine. Amino Acids 40:1271–1296. doi: 10.1007/s00726-011-0877-3