Ver registro no DEDALUS
Exportar registro bibliográfico

Metrics


Metrics:

Polymorphisms in genes involved in the Leptin-Melanocortin pathway are associated with Obesity-Related cardiometabolic alterations in a southern chilean population (2018)

  • Authors:
  • USP affiliated authors: FAJARDO, CRISTINA MORENO - FCF ; HIRATA, MARIO HIROYUKI - FCF ; HIRATA, ROSARIO DOMINGUEZ CRESPO - FCF
  • USP Schools: FCF; FCF; FCF
  • DOI: 10.1007/s40291-017-0306-8
  • Subjects: POLIMORFISMO; LEPTINA; OBESIDADE
  • Agências de fomento:
  • Language: Inglês
  • Imprenta:
    • Publisher place: Cham
    • Date published: 2018
  • Source:
  • Acesso online ao documento

    DOI or search this record in
    Informações sobre o DOI: 10.1007/s40291-017-0306-8 (Fonte: oaDOI API)
    • Este periódico é de assinatura
    • Este artigo NÃO é de acesso aberto
    Versões disponíveis em Acesso Aberto do: 10.1007/s40291-017-0306-8 (Fonte: Unpaywall API)

    Título do periódico: Molecular Diagnosis & Therapy

    ISSN: 1177-1062,1179-2000



      Não possui versão em Acesso aberto
    Informações sobre o Citescore
  • Título: Molecular Diagnosis and Therapy

    ISSN: 1177-1062

    Citescore - 2017: 2.45

    SJR - 2017: 0.923

    SNIP - 2017: 0.712


  • How to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas

    • ABNT

      MANRIQUEZ, Victor; AVILES, Jorge; SALAZAR, Luís; et al. Polymorphisms in genes involved in the Leptin-Melanocortin pathway are associated with Obesity-Related cardiometabolic alterations in a southern chilean population. Molecular Diagnosis & Therapy, Cham, v. 22, n. 1, p. 101-113, 2018. DOI: 10.1007/s40291-017-0306-8.
    • APA

      Manriquez, V., Aviles, J., Salazar, L., Saavedra, N., Seron, P., Lanas, F., et al. (2018). Polymorphisms in genes involved in the Leptin-Melanocortin pathway are associated with Obesity-Related cardiometabolic alterations in a southern chilean population. Molecular Diagnosis & Therapy, 22( 1), 101-113. doi:10.1007/s40291-017-0306-8
    • NLM

      Manriquez V, Aviles J, Salazar L, Saavedra N, Seron P, Lanas F, Fajardo CM, Hirata MH, Hirata RDC, Cerda A. Polymorphisms in genes involved in the Leptin-Melanocortin pathway are associated with Obesity-Related cardiometabolic alterations in a southern chilean population. Molecular Diagnosis & Therapy. 2018 ; 22( 1): 101-113.
    • Vancouver

      Manriquez V, Aviles J, Salazar L, Saavedra N, Seron P, Lanas F, Fajardo CM, Hirata MH, Hirata RDC, Cerda A. Polymorphisms in genes involved in the Leptin-Melanocortin pathway are associated with Obesity-Related cardiometabolic alterations in a southern chilean population. Molecular Diagnosis & Therapy. 2018 ; 22( 1): 101-113.

    Referências citadas na obra
    Haslam DW, James WP. Obesity. Lancet. 2005;366(9492):1197–209.
    Kuczmarski RJ, Flegal KM. Criteria for definition of overweight in transition: background and recommendations for the United States. Am J Clin Nutr. 2000;72(5):1074–81.
    Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640–5.
    Eckel RH, Alberti KG, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2010;375(9710):181–3.
    Ichihara S, Yamada Y. Genetic factors for human obesity. Cell Mol Life Sci. 2008;65(7–8):1086–98.
    Barsh GS, Schwartz MW. Genetic approaches to studying energy balance: perception and integration. Nat Rev Genet. 2002;3(8):589–600.
    Park HK, Ahima RS. Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism. 2015;64(1):24–34.
    Becer E, Mehmetçik G, Bareke H, Serakıncı N. Association of leptin receptor gene Q223R polymorphism on lipid profiles in comparison study between obese and non-obese subjects. Gene. 2013;529(1):16–20.
    Farooqi IS, O’Rahilly S. Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity. Nat Clin Pract Endocrinol Metab. 2008;4(10):569–77.
    Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M, et al. The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders. Hum Genet. 2010;127(3):287–94.
    Aris IM, Tint MT, Teh AL, Holbrook JD, Quah PL, Chong MF, et al. MC3R gene polymorphisms are associated with early childhood adiposity gain and infant appetite in an Asian population. Pediatr Obes. 2016;11(6):450–8.
    Zayani N, Omezzine A, Boumaiza I, Achour O, Rebhi L, Rejeb J, et al. Association of ADIPOQ, leptin, LEPR, and resistin polymorphisms with obesity parameters in Hammam Sousse Sahloul Heart Study. J Clin Lab Anal. 2017.
    García-Solís P, Reyes-Bastidas M, Flores K, García OP, Rosado JL, Méndez-Villa L, et al. Fat mass obesity-associated (FTO) (rs9939609) and melanocortin 4 receptor (MC4R) (rs17782313) SNP are positively associated with obesity and blood pressure in Mexican school-aged children. Br J Nutr. 2016;10:1–7.
    Suazo J, Hodgson MI, Obregón AM, Valladares M, Weisstaub G, Amador P, et al. Prevalence of metabolic syndrome in obese Chilean children and association with gene variants of the leptin-melanocortin system. J Pediatr Endocrinol Metab. 2013;26(11–12):1131–9.
    Vega JA, Salazar G, Hodgson MI, Cataldo LR, Valladares M, Obregón AM, et al. Melanocortin-4 receptor gene variation is associated with eating behavior in chilean adults. Ann Nutr Metab. 2016;68(1):35–41.
    Lanas F, Serón P, Saavedra N, Ruedlinger J, Salazar L. Genetic and Non-genetic determinants of circulating levels of adiponectin in a cohort of chilean subjects. Mol Diagn Ther. 2015;19(4):197–204.
    World Health Organization (2000) Obesity: preventing and managing the global epidemic. WHO Obesity Technical Report Series 894: World Health Organization Geneva S.
    Salud Md. Encuesta Nacional de Salud ENS 2009-2010.
    Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499–502.
    Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME. Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms. Circ Res. 2015;116(6):991–1006.
    Troyo-Barriga P. Obesity and dyslipidemias. Gac Med Mex. 2004;140(Suppl 2):S49–58.
    De Schutter A, Lavie CJ, Milani RV. The impact of obesity on risk factors and prevalence and prognosis of coronary heart disease-the obesity paradox. Prog Cardiovasc Dis. 2014;56(4):401–8.
    Knight ZA, Hannan KS, Greenberg ML, Friedman JM. Hyperleptinemia is required for the development of leptin resistance. PLoS One. 2010;5(6):e11376.
    Jung UJ, Choi MS. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci. 2014;15(4):6184–223.
    Jung CH, Kim MS. Molecular mechanisms of central leptin resistance in obesity. Arch Pharm Res. 2013;36(2):201–7.
    Rojas R, Aguilar-Salinas CA, Jiménez-Corona A, Shamah-Levy T, Rauda J, Avila-Burgos L, et al. Metabolic syndrome in Mexican adults: results from the National Health and Nutrition Survey 2006. Salud Publica Mex. 2010;52(Suppl 1):S11–8.
    Moreno Franco B, León Latre M, Andrés Esteban EM, Ordovás JM, Casasnovas JA, Peñalvo JL. Soluble and insoluble dietary fibre intake and risk factors for metabolic syndrome and cardiovascular disease in middle-aged adults: the AWHS cohort. Nutr Hosp. 2014;30(6):1279–88.
    Ibáñez L, Sanzana R, Salas C, Navarrete C, Cartes-Velásquez R, Rainqueo A, et al. Prevalence of metabolic syndrome in Mapuche individuals living in urban and rural environment in Chile. Rev Med Chil. 2014;142(8):953–60.
    Hinuy HM, Hirata MH, Sampaio MF, Armaganijan D, Arazi SS, Salazar LA, et al. Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals. Arq Bras Endocrinol Metabol. 2010;54(3):282–8.
    Wang TN, Huang MC, Chang WT, Ko AM, Tsai EM, Liu CS, et al. G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines. Obesity (Silver Spring). 2006;14(2):183–7.
    Portolés O, Sorlí JV, Francés F, Coltell O, González JI, Sáiz C, et al. Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain. Eur J Epidemiol. 2006;21(8):605–12.
    Mattevi VS, Zembrzuski VM, Hutz MH. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil. Int J Obes Relat Metab Disord. 2002;26(9):1179–85.
    Constantin A, Costache G, Sima AV, Glavce CS, Vladica M, Popov DL. Leptin G-2548A and leptin receptor Q223R gene polymorphisms are not associated with obesity in Romanian subjects. Biochem Biophys Res Commun. 2010;391(1):282–6.
    Boumaiza I, Omezzine A, Rejeb J, Rebhi L, Ouedrani A, Ben Rejeb N, et al. Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers. Genet Test Mol Biomarkers. 2012;16(7):726–33.
    Suriyaprom K, Tungtrongchitr R, Thawnasom K. Measurement of the levels of leptin, BDNF associated with polymorphisms LEP G2548A, LEPR Gln223Arg and BDNF Val66Met in Thai with metabolic syndrome. Diabetol Metab Syndr. 2014;6(1):6.
    Heo M, Leibel RL, Fontaine KR, Boyer BB, Chung WK, Koulu M, et al. A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference. Int J Obes Relat Metab Disord. 2002;26(5):640–6.
    Oliveira R, Cerda A, Genvigir FD, Sampaio MF, Armaganijan D, Bernik MM, et al. Leptin receptor gene polymorphisms are associated with adiposity and metabolic alterations in Brazilian individuals. Arq Bras Endocrinol Metabol. 2013;57(9):677–84.
    Quinton ND, Lee AJ, Ross RJ, Eastell R, Blakemore AI. A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Hum Genet. 2001;108(3):233–6.
    Mahmoudi T, Farahani H, Nobakht H, Dabiri R, Zali MR. Genetic Variations in Leptin and Leptin Receptor and Susceptibility to Colorectal Cancer and Obesity. Iran J Cancer Prev. 2016;9(3):e7013.
    Lee YS. Melanocortin 3 receptor gene and melanocortin 4 receptor gene mutations: the Asian perspective. Diabetes Metab Res Rev. 2012;28(Suppl 2):26–31.
    Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, et al. Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Hum Mol Genet. 2009;18(6):1140–7.
    Loos RJ. The genetic epidemiology of melanocortin 4 receptor variants. Eur J Pharmacol. 2011;660(1):156–64.
    Rotter I, Skonieczna-Żydecka K, Kosik-Bogacka D, Adler G, Rył A, Laszczyńska M. Relationships between FTO rs9939609, MC4R rs17782313, and PPARγ rs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men—a preliminary study. Clin Interv Aging. 2016;11:1723–32.
    Tan LJ, Zhu H, He H, Wu KH, Li J, Chen XD, et al. Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries. PLoS One. 2014;9(5):e96149.
    Valladares M, Domínguez-Vásquez P, Obregón AM, Weisstaub G, Burrows R, Maiz A, et al. Melanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior. Nutr Neurosci. 2010;13(2):71–8.
    Valladares M, Obregón AM, Weisstaub G, Burrows R, Patiño A, Ho-Urriola J, et al. Association between feeding behavior, and genetic polymorphism of leptin and its receptor in obese Chilean children. Nutr Hosp. 2014;31(3):1044–51.
    Obregón AM, Amador P, Valladares M, Weisstaub G, Burrows R, Santos JL. Melanocortin-3 receptor gene variants: association with childhood obesity and eating behavior in Chilean families. Nutrition. 2010;26(7–8):760–5.
    León-Mimila P, Villamil-Ramírez H, Villalobos-Comparán M, Villarreal-Molina T, Romero-Hidalgo S, López-Contreras B, et al. Contribution of common genetic variants to obesity and obesity-related traits in mexican children and adults. PLoS One. 2013;8(8):e70640.
    Abadi A, Peralta-Romero J, Suarez F, Gomez-Zamudio J, Burguete-Garcia AI, Cruz M, et al. Assessing the effects of 35 European-derived BMI-associated SNPs in Mexican children. Obesity (Silver Spring). 2016;24(9):1989–95.
    Mejía-Benítez A, Klünder-Klünder M, Yengo L, Meyre D, Aradillas C, Cruz E, et al. Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children. BMC Med Genet. 2013;14:21.
    Graff M, North KE, Richardson AS, Young KL, Mazul AL, Highland HM, et al. BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort. Int J Obes (Lond). 2017;41(5):759–68.