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Developmental trajectory of the prefrontal cortex: a systematic review of diffusion tensor imaging studies (2018)

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  • USP affiliated authors: AMARO JÚNIOR, EDSON - FM
  • USP Schools: FM
  • DOI: 10.1007/s11682-017-9761-4
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  • Language: Inglês
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    Informações sobre o DOI: 10.1007/s11682-017-9761-4 (Fonte: oaDOI API)
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    • ABNT

      SOUSA, Sonia S.; AMARO JUNIOR, Edson; CREGO, Alberto; GONÇALVES, Oscar F; SAMPAIO, Adriana. Developmental trajectory of the prefrontal cortex: a systematic review of diffusion tensor imaging studies. Brain imaging and behavior, New York, v. 12, n. 4, p. 1197-1210, 2018. Disponível em: < > DOI: 10.1007/s11682-017-9761-4.
    • APA

      Sousa, S. S., Amaro Junior, E., Crego, A., Gonçalves, O. F., & Sampaio, A. (2018). Developmental trajectory of the prefrontal cortex: a systematic review of diffusion tensor imaging studies. Brain imaging and behavior, 12( 4), 1197-1210. doi:10.1007/s11682-017-9761-4
    • NLM

      Sousa SS, Amaro Junior E, Crego A, Gonçalves OF, Sampaio A. Developmental trajectory of the prefrontal cortex: a systematic review of diffusion tensor imaging studies [Internet]. Brain imaging and behavior. 2018 ; 12( 4): 1197-1210.Available from:
    • Vancouver

      Sousa SS, Amaro Junior E, Crego A, Gonçalves OF, Sampaio A. Developmental trajectory of the prefrontal cortex: a systematic review of diffusion tensor imaging studies [Internet]. Brain imaging and behavior. 2018 ; 12( 4): 1197-1210.Available from:

    Referências citadas na obra
    Alexander, A. L., Lee, J. E., Lazar, M., & Field, A. S. (2007). Diffusion tensor imaging of the brain. Neurotherapeutics, 4(3), 316–329.
    Alger, J. R. (2012). The diffusion tensor imaging toolbox. The Journal of Neuroscience, 32(22), 7418–7428. .
    Asato, M. R., Terwilliger, R., Woo, J., & Luna, B. (2010). White matter development in adolescence: a DTI study. Cerebral Cortex, 20, 2122–2131. .
    Ashtari, M., Cervellione, K. L., Hasan, K. M., Wu, J., McIlree, C., Kester, H., Ardekani, B. A., Roofeh, D., Szeszko, P. R., & Kumra, S. (2007). White matter development during late adolescence in healthy males: a cross- sectional diffusion tensor imaging study. NeuroImage, 35(2), 501–510.
    Assaf, Y., & Pasternak, O. (2008). Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review. Journal of Molecular Neuroscience, 34(1), 51–61. .
    Aung, W. Y., Mar, S., & Benzinger, T. L. (2013). Diffusion tensor MRI as a biomarker in axonal and myelin damage. Imaging in Medicine, 5(5), 427–440. .
    Barnea-Goraly, N., Menon, V., Eckert, M., Tamm, L., Bammer, R., Karchemskiy, A., Dant, C. C., & Reiss, A. L. (2005). White matter development during childhood and adolescence: a cross- sectional diffusion tensor imaging study. Cerebral Cortex, 15, 1848–1854.
    Bartzokis, G., Lu, P. H., Heydari, P., Couvrette, A., Lee, G. J., Kalashyan, G., Kalashyan, G., Freeman, F., Grinstead, J. W., Villablanca, P., Finn, J. P., Mintz, J., Alger, J. R., & Altshuler, L. L. (2012). Multimodal magnetic resonance imaging assessment of white matter aging trajectories over the lifespan of healthy individuals. Biological Psychiatry, 72, 1026–1034.
    Bava, S., Thayer, R., Jacobus, J., Ward, M., Jernigan, T. L., & Tapert, S. F. (2010). Longitudinal characterization of white matter maturation during adolescence. Brain Research, 1327, 38–46.
    Beaulieu, C. (2002). The basis of anisotropic water diffusion in the nervous system—a technical review. NMR in Biomedicine, 15(7–8), 435–455. .
    Bennett, E. L., Diamond, M. C., Krech, D., & Rosenzweig, M. R. (1964). Chemical and anatomical plasticity of brain: changes in brain through experience, demanded by learning theories, are found in experiments with rats. Science, 146(3644), 610–619. .
    Bonekamp, D., Nagae, L. M., Degaonkar, M., Matson, M., Abdall, W. M. A., Barker, P. B., Mori, S., & Horská, A. (2007). Diffusion tensor imaging in children and adolescents: reproducibility, hemispheric, and age-related differences. NeuroImage, 34(2), 733–742.
    Casey, B. J., Giedd, J. N., & Thomas, K. M. (2000). Structural and functional brain development and its relation to cognitive development. Biological Psychology, 54(1–3), 241–257. .
    Chilla, G. S., Tan, C. H., Xu, C., & Poh, C. L. (2015). Diffusion weighted magnetic resonance imaging and its recent trend-a survey. Quantitative Imaging in Medicine and Surgery, 5(3), 407–422. .
    Colby, J. B., Van Horn, J. D., & Sowell, E. R. (2011). Quantitative in vivo evidence for broad regional gradients in the timing of white matter maturation during adolescence. NeuroImage, 54(1), 25–31. .
    Deoni, S. C. L., Mercure, E., Blasi, A., Gasston, D., Thomson, A., Johnson, M., Williams, S. C., & Murphy, D. G. M. (2011). Mapping infant brain myelination with magnetic resonance imaging. The Journal of Neuroscience, 31(2), 784–791.
    Ding, A. Y., Li, Q., Zhou, I. Y., Ma, S. J., Tong, G., McAlonan, G. M., & Wu, E. X. (2013). MR diffusion tensor imaging detects rapid microstructural changes in amygdala and hippocampus following fear conditioning in mice. PLoS One, 8(1), e51704. .
    Dubois, J., Dehaene-Lambertz, G., Kulikova, S., Poupon, C., Huppi, P. S., & Hertz-Pannier, L. (2013). The early development of brain white matter: a review of imaging studies in fetuses, newborns and infants. Neuroscience, 276, 48–71. .
    Durston, S., Hulshoff Pol, H. E., Casey, B. J., Giedd, J. N., Buitelaar, J. K., & van Engeland, H. (2001). Anatomical MRI of the developing human brain: what have we learned? Journal of the American Academy of Child and Adolescent Psychiatry, 40(9), 1012–1020.
    Eluvathingal, T. J., Hasan, K. M., Kramer, L., Fletcher, J. M., & Ewing-Cobbs, L. (2007). Quantitative diffusion tensor tractography of association and projection fibers in normally developing children and adolescents. Cerebral Cortex, 17, 2760–2768.
    Fields, R. D. (2005). Myelination: an overlooked mechanism of synaptic plasticity? The Neuroscientist, 11(6), 528–531. .
    Fields, R. D. (2008). White matter in learning, cognition and psychiatric disorders. Trends in Neurosciences, 31(7), 361–370.
    Fox, R. J., Cronin, T., Lin, J., Wang, X., Sakaie, K., Ontaneda, D., Mahmoud, S. Y., Lowe, M. J., & Phillips, M. D. (2011). Measuring myelin repair and axonal loss with diffusion tensor imaging. AJNR. American Journal of Neuroradiology, 32(1), 85–91. .
    Froeling, M., Pullens, P., & Leemans, A. (2016). DTI analysis methods: region of interest analysis. pp. 175–182. .
    Gallo, G. (2011). The cytoskeletal and signaling mechanisms of axon collateral branching. Developmental Neurobiology, 71(3), 201–220. .
    Gibson, D. A., & Ma, L. (2011). Developmental regulation of axon branching in the vertebrate nervous system. Development, 138(2), 183–195. .
    Giedd, J. N. (2004). Structural magnetic resonance imaging of the adolescent brain. Annals of the New York Academy of Sciences, 1021, 77–85. .
    Giedd, J. N. (2008). The teen brain: insights from neuroimaging. The Journal of Adolescent Health, 42(4), 335–343. .
    Giedd, J. N., & Rapoport, J. L. (2010). Structural MRI of pediatric brain development: what have we learned and where are we going? Neuron, 67(5), 728–734. .
    Giedd, J. N., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., Paus, T., Evans, A. C., & Rapoport, J. L. (1999). Brain development during childhood and adolescence: a longitudinal MRI study. Nature Neuroscience, 2, 861–863.
    Giedd, J. N., Clasen, L. S., Lenroot, R., Greenstein, D., Wallace, G. L., Ordaz, S., Molloy, E. A., Blumenthal, J. D., Tossell, J. W., Stayer, C., Samango-Sprouse, C. A., Shen, D., Davatzikos, C., & Chrousos, G. P. (2006). Puberty-related influences on brain development. Molecular and Cellular Endocrinology, 254–255, 154–162. .
    Giorgio, A., Watkins, K. E., Douaud, G., James, A. C., James, S., De Stefano, N., Matthews, P. M., Smith, S. M., & Johansen-Berg, H. (2008). Changes in white matter microstructure during adolescence. NeuroImage, 39, 52–61.
    Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F. 3rd, Herman, D. H., Clasen, L. S., Toga, A. W., Rapoport, J. L., & Thompson, P. M. (2004). Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences of the United States of America, 101(21), 8174–8179.
    Hagmann, P., Jonasson, L., Maeder, P., Thiran, J.-P., Wedeen, V. J., & Meuli, R. (2006). Understanding diffusion MR imaging techniques: from scalar diffusion-weighted imaging to diffusion tensor imaging and beyond. RadioGraphics, 26, 205–223.
    Hasan, K. M., Alexander, A. L., & Narayana, P. A. (2004). Does fractional anisotropy have better noise immunity characteristics than relative anisotropy in diffusion tensor MRI? An analytical approach. Magnetic Resonance in Medicine, 51, 413–417.
    Hasan, K. M., Sankar, A., Halphen, C., Kramer, L. A., Brandt, M. E., Juranek, J., Cirino, P. T., Fletcher, J. M., Papanicolaou, A. C., & Ewing-Cobbs, L. (2007). Development and organization of the human brain tissue compartments across the lifespan using diffusion tensor imaging. Neuroreport, 18(16), 1735–1739.
    Huttenlocher, P. R. (1979). Synaptic density in human frontal cortex- developmental changes and effects of aging. Brain Research, 163, 195–205.
    Jones, D. K., & Cercignani, M. (2010). Twenty-five pitfalls in the analysis of diffusion MRI Data. NMR in Biomedicine, 23, 803–820.
    Klingberg, T., Vaidya, C. J., Gabrieli, J. D., Moseley, M. E., & Hedehus, M. (1999). Myelination and organization of the frontal white matter in children: a diffusion tensor MRI study (Abstract). Neuroreport, 10(13), 2817–2821.
    Kraus, M. F., Susmaras, T., Caughlin, B. P., Walker, C. J., Sweeney, J. A., & Little, D. M. (2007). White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study. Brain, 130, 2508–2519.
    Krogsrud, S. K., Fjell, A. M., Tamnes, C. K., Grydeland, H., Mork, L., Due-Tonnessen, P., Biornerud, A., Sampaio-Baptista, C., Anderson, J., Johansen-Berg, H., & Walhovd, K. B. (2016). Changes in white matter microstructure in the developing brain—a longitudinal diffusion tensor imaging study of children from 4 to 11 years of age. NeuroImage, 124(Pt A), 473–486. .
    Kumar, R., Nguyen, H. D., Macey, P. M., Woo, M. A., & Harper, R. M. (2012). Regional brain axial and radial diffusivity changes during development. Journal of Neuroscience Research, 90(2), 346–355.
    Le Bihan, D. (2003). Looking into the functional architecture of the brain with diffusion MRI. Nature, 4, 469–480.
    Le Bihan, D., Mangin, J.-F., Poupon, C., Clark, C. A., Pappata, S., Molko, N., & Chabriat, H. (2001). Diffusion tensor imaging: concepts and applications. Journal of Magnetic Resonance Imaging, 13, 534–546.
    Lebel, C., & Beaulieu, C. (2011). Longitudinal development of human brain wiring continues from childhood into adulthood. The Journal of Neuroscience, 31(30), 10937–10947.
    Lebel, C., Walker, L., Leemans, A., Phillips, L., & Beaulieu, C. (2008). Microstructural maturation of the human brain from childhood to adulthood. NeuroImage, 40, 1044–1055.
    Lenroot, R. K., & Giedd, J. N. (2006). Brain development in children and adolescents: Insights from anatomical magnetic resonance imaging. Neuroscience and Biobehavioral Reviews, 30, 718–729.
    Li, T. Q., & Noseworthy, M. D. (2002). Mapping the development of white matter tracts with diffusion tensor imaging. Developmental Science, 5(3), 293–300.
    Lobel, U., Sedlacik, J., Gullmar, D., Kaiser, W. A., Reichenbach, J. R., & Mentzel, H. J. (2009). Diffusion tensor imaging: the normal evolution of ADC, RA, FA, and eigenvalues studied in multiple anatomical regions of the brain. Neuroradiology, 51(4), 253–263. .
    Lopez-Caneda, E., Mota, N., Crego, A., Velasquez, T., Corral, M., Holguín, S. R., & Cadaveira, F. (2014). Neurocognitive anomalies associated with the binge drinking pattern of alcohol consumption in adolescents and young people: a review. Adicciones, 26(4), 334–359.
    Madsen, K. S., Baaré, W.F.C., Vestergaard, M., Skimminge, A., Ejersbo, L. R., Ramsøy, T. Z., Gerlach, C., Akeson, P., Paulson, O. B., & Jernigan, T. L. (2010). Response inhibition is associated with white matter microstructure in children. Neuropsychologia, 48, 854–862.
    Martino, J., De Witt Hamer, P. C., Berger, M. S., Lawton, M. T., Arnold, C. M., de Lucas, E. M., & Duffau, H. (2013). Analysis of the subcomponents and cortical terminations of the perisylvian superior longitudinal fasciculus: a fiber dissection and DTI tractography study. Brain Structure and Function, 218, 105–121.
    Medana, I. M., & Esiri, M. M. (2003). Axonal damage: a key predictor of outcome in human CNS diseases. Brain, 126, 515–530.
    Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Annals of Internal Medicine, 151(4), 264–269.
    Moon, W.-J., Provenzale, J., Sarikaya, B., Ihn, Y. K., Morlese, J., Chen, S., & DeBellis, M. D. (2011). Diffusion tensor imaging assessment of white matter maturation in childhood and adolescence. American Journal of Roentgenology, 197(3), 704–712.
    Mori, S., & Zhang, J. (2006). Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron, 51(5), 527–539. .
    Muftuler, L. T., Davis, E. P., Buss, C., Solodkin, A., Su, M. Y., Head, K. M., Hasso, A. N., & Sandman, C. A. (2012). Development of white matter pathways in typically developing preadolescent children. Brain Research, 1466, 33–43. .
    Mukherjee, P., Berman, J. I., Chung, S. W., Hess, C. P., & Henry, R. G. (2008). Diffusion tensor MR imaging and fiber tractography: theoretic underpinnings. AJNR. American Journal of Neuroradiology, 29(4), 632–641. .
    Nagy, Z., Westerberg, H., & Klingberg, T. (2004). Maturation of white matter is associated with the development of cognitive functions during childhood. Journal of Cognitive Neuroscience, 16(7), 1227–1233.
    Neil, J., Miller, J., Mukherjee, P., & Huppi, P. S. (2002). Diffusion tensor imaging of normal and injured developing human brain—a technical review. NMR in Biomedicine, 15(7–8), 543–552. .
    Nishikawa, R. M., Lützkendorf, R., Whiting, B. R., Hertel, F., Heidemann, R., Thiel, A., Luchtmann, M., Plaumann, M., Stadler, J., Baecke, S., & Bernarding, J. (2013). Non-invasive high-resolutiontracking of human neuronal pathways: diffusion tensor imaging at 7T with 1.2 mm isotropic voxel size. 8668, 866846. .
    Paus, T. (2010). Growth of white matter in the adolescent brain: myelin or axon? Brain and Cognition, 72, 26–35.
    Paus, T., Zijdenbos, A., Worsley, K., Collins, D. L., Blumenthal, J., Giedd, J. N., Rapoport, J. L., & Evans, A. C. (1999). Structural maturation of neural pathways in children and adolescents: in vivo study. Science, 283(5409), 1908–1911.
    Paus, T., Collins, D. L., Evans, A. C., Leonard, G., Pike, B., & Zijdenbos, A. (2001). Maturation of white matter in the human brain: a review of magnetic resonance studies. Brain Research Bulletin, 54(3), 255–266.
    Petanjek, Z., Judaš, M., Šimić, G., Rašin, M. R., Uylings, H. B. M., Rakic, P., & Kostovića, I. (2011). Extraordinary neoteny of synaptic spines in the human prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America, 108(32), 13281–13286. .
    Pierpaoli, C., & Basser, P. J. (1996). Toward a quantitative assessment of diffusion anisotropy. Magnetic Resonance in Medicine, 36(6), 893–906. .
    Pierpaoli, C., Jezzard, P., Basser, P. J., Barnett, A., & Di Chiro, G. (1996). Diffusion tensor MR imaging of the human brain. Radiology, 201, 637–648.
    Preziosa, P., Pagani, E., Morelli, M. E., Copetti, M., Martinelli, V., Pirro, F., Falini, A., Comi, G., Filippi, M., & Rocca, M. A. (2017). DT MRI microstructural cortical lesion damage does not explain cognitive impairment in MS. Multiple Sclerosis. 1352458516689147. .
    Qiu, D., Tan, L.-H., Zhou, K., & Khong, P.-L. (2008). Diffusion tensor imaging of normal white matter maturation from late childhood to young adulthood: voxel-wise evaluation of mean diffusivity, fractional anisotropy, radial and axial diffusivities, and correlation with reading development. NeuroImage, 41, 223–232.
    Qiu, M., Li, Q., Liu, G., Xie, B., & Wang, J. (2010). Voxel-based analysis of white matter during adolescence and young adulthood. Brain & Development, 32, 531–537.
    Roosendaal, S. D., Geurts, J. J., Vrenken, H., Hulst, H. E., Cover, K. S., Castelijns, J. A., Pouwels, J. A., & Barkhof, F. (2009). Regional DTI differences in multiple sclerosis patients. NeuroImage, 44(4), 1397–1403. .
    Schmithorst, V. J., Wilke, M., Dardzinski, B. J., & Holland, S. K. (2005). Cognitive functions correlate with white matter architecture in a normal pediatric population: a diffusion tensor MRI study. Human Brain Mapping, 26(2), 139–147. .
    Schneider, J.F.L., Il’yasov, K. A., Hennig, J., & Martin, E. (2004). Fast quantitative diffusion-tensor imaging of cerebral white matter from the neonatal period to adolescence. Neuroradiology, 46, 258–266.
    Scholz, J., Klein, M. C., Behrens, T. E., & Johansen-Berg, H. (2009). Training induces changes in white-matter architecture. Nature Neuroscience, 12(11), 1370–1371. .
    Shaw, P., Kabani, N. J., Lerch, J. P., Eckstrand, K., Lenroot, R., Gogtay, N., Greenstein, D., Clasen, L., Evans, A., Rapoport, J. L., Giedd, J. N., & Wise, S. P. (2008). Neurodevelopmental trajectories of the human cerebral cortex. The Journal of Neuroscience, 28(14), 3586–3594. .
    Simmonds, D. J., Hallquist, M. N., Asato, M., & Luna, B. (2014). Developmental stages and sex differences of white matter and behavioral development through adolescence: a longitudinal diffusion tensor imaging (DTI) study. NeuroImage, 92, 356–368. .
    Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C. E., Watkins, K. E., Ciccarelli, O., Cader, M. Z., Matthews, P. M., & Behrens, T. E. (2006). Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. NeuroImage, 31(4), 1487–1505. .
    Snaidero, N., & Simons, M. (2014). Myelination at a glance. Journal of Cell Science, 127, 2999–3004.
    Snook, L., Paulson, L.-A., Roy, D., Phillips, L., & Beaulieu, C. (2005). Diffusion tensor imaging of neurodevelopment in children and young adults. NeuroImage, 26, 1164–1173.
    Snook, L., Plewes, C., & Beaulieu, C. (2007). Voxel based versus region of interest analysis in diffusion tensor imaging of neurodevelopment. NeuroImage, 34, 243–252.
    Soares, J. M., Marques, P., Alves, V., & Sousa, N. (2013). A hitchhiker’s guide to diffusion tensor imaging. Frontiers in Neuroscience, 7, 31. .
    Song, S. K., Sun, S. W., Ramsbottom, M. J., Chang, C., Russell, J., & Cross, A. H. (2002). Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. NeuroImage, 17(3), 1429–1436. .
    Song, S.-K., Sun, S.-W., Ju, W.-K., Lin, S.-J., Cross, A. H., & Neufeld, A. H. (2003). Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. NeuroImage, 20, 1714–1722.
    Sun, S. W., Liang, H. F., Trinkaus, K., Cross, A. H., Armstrong, R. C., & Song, S. K. (2006). Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum. Magnetic Resonance in Medicine, 55(2), 302–308. .
    Sun, S.-W., Liang, H.-F., Cross, A. H., & Song, S.-K. (2008). Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging. NeuroImage, 40(1), 1–10. .
    Taki, Y., Thyreau, B., Hashizume, H., Sassa, Y., Takeuchi, H., Wu, K., Kotozaki, Y., Nouchi, R., Asano, K., Fukuda, H., & Kawashima, R. (2013). Linear and curvilinear correlations of brain white matter volume, fractional anisotropy, and mean diffusivity with age using voxel-based and region-of-interest analyses in 246 healthy children. Human Brain Mapping, 34(8), 1842–1856. .
    Tamnes, C. K., Østby, Y., Fjell, A. M., Westlye, L. T., Due-Tønnessen, P., & Walhovd, K. B. (2010). Brain maturation in adolescence and young adulthood: regional age-related changes in cortical thickness and white matter volume and microstructure. Cerebral Cortex, 20, 534–548.
    Thomason, M. E., & Thompson, P. M. (2011). Diffusion imaging, white matter, and psychopathology. Annual Review of Clinical Psychology, 7, 63–85.
    Uda, S., Matsui, M., Tanaka, C., Uematsu, A., Miura, K., Kawana, I., & Noguchi, K. (2015). Normal development of human brain white matter from infancy to early adulthood: a diffusion tensor imaging study. Developmental Neuroscience, 37(2), 182–194. .
    Urger, S. E., De Bellis, M. D., Hooper, S. R., Woolley, D. P., Chen, S. D., & Provenzale, J. (2015). The superior longitudinal fasciculus in typically developing children and adolescents: diffusion tensor imaging and neuropsychological correlates. Journal of Child Neurology, 30(1), 9–20. .
    Westin, C. F., Maier, S. E., Mamata, H., Nabavi, A., Jolesz, F. A., & Kikinis, R. (2002). Processing and visualization for diffusion tensor MRI. Medical Image Analysis, 6, 93–108.
    Xie, M., Wang, Q., Wu, T. H., Song, S. K., & Sun, S. W. (2011). Delayed axonal degeneration in slow Wallerian degeneration mutant mice detected using diffusion tensor imaging. Neuroscience, 197, 339–347. .