Antitrypanosomal aminobenzimidazoles: hit to lead expansion of new chemical entities against Trypanosoma cruzi and Leishmania infantum (2019)
- Authors:
- Ferreira, R. A. A. - Universidade Estadual de Campinas (UNICAMP)
- Oliveira Junior, C. R. - Universidade Estadual de Campinas (UNICAMP)
- Martinez, P. G. - Universidade Estadual de Campinas (UNICAMP)
- Soares, B. M. - Universidade Estadual de Campinas (UNICAMP)
- Koovits, P. - Universidade Estadual de Campinas (UNICAMP)
- Duarte, Simone Michelan
- Andricopulo, Renata Krogh
- Ferreira, Leonardo Luiz Gomes
- Chelucci, Rafael Consolin
- Magalhães, Luma Godoy
- Andricopulo, Adriano Defini
- Mowbray, C. E.
- Kratz, J. M.
- Dias, L. C. - Universidade Estadual de Campinas (UNICAMP)
- USP affiliated authors: DUARTE, SIMONE MICHELAN - IFSC ; ANDRICOPULO, RENATA KROGH - IFSC ; ANDRICOPULO, ADRIANO DEFINI - IFSC ; FERREIRA, LEONARDO LUIZ GOMES - IFSC ; CHELUCCI, RAFAEL CONSOLIN - IFSC ; MAGALHÃES, LUMA GODOY - IFSC
- Unidade: IFSC
- Subjects: TRYPANOSOMA CRUZI; LEISHMANIA INFANTUM; PLANEJAMENTO DE FÁRMACOS
- Keywords: Drug discovery; Aminobenzimidazoles; SAR; Chagas disease; Leishmaniasis
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título do periódico: Anais eletrônicos
- Conference titles: Brazilian Symposium on Medicinal Chemistry - BrazMedChem
-
ABNT
FERREIRA, R. A. A. et al. Antitrypanosomal aminobenzimidazoles: hit to lead expansion of new chemical entities against Trypanosoma cruzi and Leishmania infantum. 2019, Anais.. Campinas: Galoá, 2019. Disponível em: https://proceedings.science/p/107147. Acesso em: 23 abr. 2024. -
APA
Ferreira, R. A. A., Oliveira Junior, C. R., Martinez, P. G., Soares, B. M., Koovits, P., Duarte, S. M., et al. (2019). Antitrypanosomal aminobenzimidazoles: hit to lead expansion of new chemical entities against Trypanosoma cruzi and Leishmania infantum. In Anais eletrônicos. Campinas: Galoá. Recuperado de https://proceedings.science/p/107147 -
NLM
Ferreira RAA, Oliveira Junior CR, Martinez PG, Soares BM, Koovits P, Duarte SM, Andricopulo RK, Ferreira LLG, Chelucci RC, Magalhães LG, Andricopulo AD, Mowbray CE, Kratz JM, Dias LC. Antitrypanosomal aminobenzimidazoles: hit to lead expansion of new chemical entities against Trypanosoma cruzi and Leishmania infantum [Internet]. Anais eletrônicos. 2019 ;[citado 2024 abr. 23 ] Available from: https://proceedings.science/p/107147 -
Vancouver
Ferreira RAA, Oliveira Junior CR, Martinez PG, Soares BM, Koovits P, Duarte SM, Andricopulo RK, Ferreira LLG, Chelucci RC, Magalhães LG, Andricopulo AD, Mowbray CE, Kratz JM, Dias LC. Antitrypanosomal aminobenzimidazoles: hit to lead expansion of new chemical entities against Trypanosoma cruzi and Leishmania infantum [Internet]. Anais eletrônicos. 2019 ;[citado 2024 abr. 23 ] Available from: https://proceedings.science/p/107147 - Indoles hit-to-lead for chagas disease: lessons learned within the LOLA consortium
- Evaluation and discovery of novel benzothiazole derivatives as promising hits against Leishmania infantum
- Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease
- Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents
- Antitrypanosomal Benzoxazinone series: hit-to-lead campaign and multiparametric optimization
- SAR studies on a series of reversible competitive inhibitors of cruzain from Trypanosoma cruzi
- Structure-activity relationships of novel N-imidazoylpiperazines with potent anti-trypanosoma cruzi activity
- Multiparameter optimization of Trypanocidal cruzain inhibitors with in vivo activity and favorable pharmacokinetics
- Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids
- 2-aminobenzimidazoles for leishmaniasis: from initial hit discovery to in vivo profiling
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