Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning (2023)
- Authors:
- Peixoto, Álbert S.
- Moreno, Mayara F.
- Castro, Érique de
- Perandini, Luiz A.
- Belchior, Thiago
- Oliveira, Tiago E.
- Vieira, Thayna S.
- Gilio, Gustavo R.
- Tomazelli, Caroline A.
- Leonardi, Bianca F.
- Milene Ortiz-Silva
- Silva Junior, Luciano P.
- Moretti, Eduardo H.
- Steiner, Alexandre Alarcon
- Festuccia, William Tadeu Lara
- Peixoto, Álbert S.
- USP affiliated authors: STEINER, ALEXANDRE ALARCON - ICB ; FESTUCCIA, WILLIAM TADEU LARA - ICB ; PEIXOTO, ÁLBERT SOUZA - ICB ; MORENO, MAYARA FRANZOI - ICB ; PERANDINI, LUIZ AUGUSTO BUORO - ICB ; OLIVEIRA, THIAGO BELCHIOR DE - ICB ; SILVA, TIAGO EUGÊNIO OLIVEIRA DA - ICB ; VIEIRA, THAYNA DOS SANTOS - ICB ; GILIO, GUSTAVO RENAN - ICB ; TOMAZELLI, CAROLINE APARECIDA - ICB ; CASTRO, ÉRIQUE DE - ICB ; SILVA JUNIOR, LUCIANO PEDRO DA - ICB ; MORETTI, EDUARDO HERMÓGENES - ICB
- Unidade: ICB
- DOI: 10.1007/s13105-023-00970-4
- Subjects: FISIOLOGIA; IMUNOLOGIA; CARCINOMA HEPATOCELULAR; HEPATOPATIAS; FÍGADO GORDUROSO; TERMOGÊNESE; INFLAMAÇÃO; CITOCINAS; CAMUNDONGOS; FIBROBLASTOS
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher: Springer Dordrecht
- Publisher place: Dordrecht
- Date published: 2023
- Source:
- Título do periódico: Journal of Physiology and Biochemistry
- ISSN: 1877-8755
- Volume/Número/Paginação/Ano: p. 1-13, 2023
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
-
ABNT
PEIXOTO, Álbert S. et al. Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning. Journal of Physiology and Biochemistry, p. 1-13, 2023Tradução . . Disponível em: https://doi.org/10.1007/s13105-023-00970-4. Acesso em: 20 maio 2024. -
APA
Peixoto, Á. S., Moreno, M. F., Castro, É. de, Perandini, L. A., Belchior, T., Oliveira, T. E., et al. (2023). Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning. Journal of Physiology and Biochemistry, 1-13. doi:10.1007/s13105-023-00970-4 -
NLM
Peixoto ÁS, Moreno MF, Castro É de, Perandini LA, Belchior T, Oliveira TE, Vieira TS, Gilio GR, Tomazelli CA, Leonardi BF, Milene Ortiz-Silva, Silva Junior LP, Moretti EH, Steiner AA, Festuccia WTL. Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning [Internet]. Journal of Physiology and Biochemistry. 2023 ; 1-13.[citado 2024 maio 20 ] Available from: https://doi.org/10.1007/s13105-023-00970-4 -
Vancouver
Peixoto ÁS, Moreno MF, Castro É de, Perandini LA, Belchior T, Oliveira TE, Vieira TS, Gilio GR, Tomazelli CA, Leonardi BF, Milene Ortiz-Silva, Silva Junior LP, Moretti EH, Steiner AA, Festuccia WTL. Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning [Internet]. Journal of Physiology and Biochemistry. 2023 ; 1-13.[citado 2024 maio 20 ] Available from: https://doi.org/10.1007/s13105-023-00970-4 - Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in coldacclimated mice
- Chloroquine attenuates diet-induced obesity and glucose intolerance through a mechanism that might involve FGF-21, but not UCP-1-mediated thermogenesis and inhibition of adipocyte autophagy
- UCP1-independent mechanisms involved in the increased energy expenditure and protection against obesity induced by fish oil in mice
- Deficiency of mTORC1 accelerates, while deficiency of mTORC2 blocks the development and progression of steatosis to steatohepatitis and hepatocellular carcinoma induced by PTEN-deletion in hepatocytes
- A leukotriene-dependent spleen-liver axis drives TNF production in systemic inflammation
- Futile cycle of β-oxidation and de novo lipogenesis are associated with essential fatty acids depletion in lipoatrophy
- Mild-cold water swimming does not exacerbate white adipose tissue browning and brown adipose tissue activation in mice
- PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity
- Rictor/mTORC2 is a major mediator of hepatic steatosis, steatohepatitis and hepatocellular carcinoma progression induced by PTEN deletion in hepatocytes
- Lipoatrophy-associated insulin resistance and hepatic steatosis are attenuated by intake of diet rich in omega 3 fatty acids
Informações sobre o DOI: 10.1007/s13105-023-00970-4 (Fonte: oaDOI API)
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